貨號	規(guī)格	價(jià)格	上海	北京	武漢	南京
S84945-5mg	99.7%	￥410.00 S84945-5mg ￥410.00 現(xiàn)貨	6 6	-	-	-
S84945-10mg	99.7%	￥603.00 S84945-10mg ￥603.00 現(xiàn)貨	7 7	-	-	-
S84945-25mg	99.7%	￥1160.00 S84945-25mg ￥1160.00 現(xiàn)貨	6 6	-	-	-
S84945-50mg	≥99%	￥1870.00 S84945-50mg ￥1870.00 2-3天	0 貨期：2-3天	-	-	-

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產(chǎn)品介紹

AX20017 is a small-molecule protein kinase G (PknG) inhibitor with an IC50 of 0.39 μM.

產(chǎn)品描述：

AX20017 is a small-molecule protein kinase G (PknG) inhibitor with an IC50 of 0.39 μM.

靶點(diǎn)：

IC50: 0.39 μM (PknG);Antibacterial

體外研究：

The compound AX20017 inhibitor is bound deep within a narrow pocket formed by the inter lobe cleft of the PknG domain. The main chain Glu233:O and Val235:NH of PknG form hydrogen bonds with AX20017.AX20017 results in mycobacterial transfer to lysosomes and killing of the mycobacteria. AX20017 does not affect the human kinases, whereas the activity of PknG is effectively inhibited. AX20017 does not affect cellular morphology, membrane ruffling, or macropinocytosis

參考文獻(xiàn)：

1. Walburger A, et al. Protein kinase G from pathogenic mycobacteria promotes survival within macrophages. Science. 2004 Jun 18;304(5678):1800-4. 2. Santhi N, et al. Insights from the molecular docking of withanolide derivatives to the target protein PknG from Mycobacterium tuberculosis. Bioinformation. 2011;7(1):1-4. 3. Scherr N, et al. Structural basis for the specific inhibition of protein kinase G, a virulence factor of Mycobacterium tuberculosis. Proc Natl Acad Sci U S A. 2007 Jul 17;104(29):12151-6.

溶解性：

Soluble in DMSO

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	3.783 ml	18.915 ml	37.83 ml
5 mM	0.757 ml	3.783 ml	7.566 ml
10 mM	0.378 ml	1.891 ml	3.783 ml
50 mM	0.076 ml	0.378 ml	0.757 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻(xiàn)

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