品牌	貨號	產品規格	價格(RMB)	庫存（上海）	北京	武漢	南京
源葉(MedMol)	S84875-5mg	98%	￥340.00元	8	-	-	-
源葉(MedMol)	S84875-10mg	98%	￥578.00元	9	-	-	-
源葉(MedMol)	S84875-50mg	98%	￥2584.00元	>10	-	-	-

產品介紹

Glutaminase C-IN-1 (Compound 968) is an allosteric inhibitor of Glutaminase C that inhibits cancer cell growth without affecting their normal cellular counterparts

產品描述： Glutaminase C-IN-1 (Compound 968) is an allosteric inhibitor of Glutaminase C that inhibits cancer cell growth without affecting their normal cellular counterparts

靶點： Glutaminase C;Glutaminase

體外研究：
Glutaminase C-IN-1 (Compound 968) (10 μM; 14 d) inhibits cellular transformation in NIH 3T3 cells. Glutaminase C-IN-1 (10 μM; 6 d) blocks the signaling activity of a specific target of Dbl. Glutaminase C-IN-1 blocks the transforming activity of human breast cancer cells. Glutaminase C-IN-1 (10 μM) blocks glutaminolysis in transformed cells. Glutaminase C-IN-1 preferentially binds to the monomeric state of Glutaminase C. Cell Viability Assay Cell Line: MDA-MB231 cells, SKBR3 cells, and NIH 3T3 cells Concentration: 10 μM Incubation Time: 5 h Result: Inhibited cell growth.

體內研究：
Glutaminase C-IN-1 (Compound 968) (200 μg/mouse; i.p.; daily for 12 days) reduces tumor volume in mice. Animal Model: SCID mice with P493 B lymphoma cells Dosage: 200 μg/mouse Administration: Intraperitoneal injection, daily for 12 days Result: Caused a ~50% reduction in the size of the tumors.

參考文獻：
1. Wang JB, et al. Targeting mitochondrial glutaminase activity inhibits oncogenic transformation. Cancer Cell. 2010 Sep 14;18(3):207-19. 2. Stalnecker CA, et al. Mechanism by which a recently discovered allosteric inhibitor blocks glutamine metabolism in transformed cells. Proc Natl Acad Sci U S A. 2015 Jan 13;112(2):394-9.

溶解性： Soluble in DMSO

保存條件： -20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.103 ml	10.517 ml	21.034 ml
5 mM	0.421 ml	2.103 ml	4.207 ml
10 mM	0.21 ml	1.052 ml	2.103 ml
50 mM	0.042 ml	0.21 ml	0.421 ml

注意：

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參考文獻

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Glutaminase C-IN-1 98%

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