貨號	規(guī)格	價格	上海	北京	武漢	南京
S84860-5mg	99.7%	￥140.00 S84860-5mg ￥140.00 現(xiàn)貨	9 9	-	-	-
S84860-10mg	99.7%	￥240.00 S84860-10mg ￥240.00 現(xiàn)貨	8 8	-	-	-
S84860-25mg	99.7%	￥500.00 S84860-25mg ￥500.00 現(xiàn)貨	7 7	-	-	-
S84860-50mg	99.7%	￥850.00 S84860-50mg ￥850.00 現(xiàn)貨	3 3	-	-	-

產(chǎn)品介紹

CL-82198 is a selective inhibitor of MMP-13. CL-82198 binds to the entire S1’ pocket of MMP-13, which is the basis for its selectivity towards MMP-13 and the lack of inhibitory activities against other MMPs. CL-82198 is a pharmacologic treatment for preventing osteoarthritis (OA) progression

產(chǎn)品描述：

靶點：

MMP

體內(nèi)研究：

CL82198 (1-10 mg/kg; i.p.; every other day for 12 weeks) prevents and decelerates MLI-induced osteoarthritis progression

參考文獻：

1. Rath T et al. Matrix metalloproteinase-13 is regulated by toll-like receptor-9 in colorectal cancer cells and mediates cellular migration. Oncol Lett. 2011 May;2(3):483-488. 2. George J, et al. MMP-13 deletion decreases profibrogenic molecules and attenuates N-nitrosodimethylamine-induced liver injury and fibrosis in mice. J Cell Mol Med. 2017 Dec;21(12):3821-3835. 3. Wohlauer M et al. Nebulized hypertonic saline attenuates acute lung injury following trauma and hemorrhagic shock via inhibition of matrix metalloproteinase-13. Crit Care Med. 2012 Sep;40(9):2647-53. 4. Wang M,et al. MMP13 is a critical target gene during the progression of osteoarthritis. Arthritis Res Ther. 2013 Jan 8;15(1):R5.

溶解性：

Soluble in DMSO

保存條件：

2-8℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	3.307 ml	16.536 ml	33.072 ml
5 mM	0.661 ml	3.307 ml	6.614 ml
10 mM	0.331 ml	1.654 ml	3.307 ml
50 mM	0.066 ml	0.331 ml	0.661 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

質(zhì)檢證書(COA)

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CL 82198