貨號	規格	價格	上海	北京	武漢	南京
S84859-5mg	≥95%	￥770.00 S84859-5mg ￥770.00 2-3天	0 貨期：2-3天	-	-	-
S84859-10mg	≥95%	￥1460.00 S84859-10mg ￥1460.00 2-3天	0 貨期：2-3天	-	-	-
S84859-50mg	≥95%	￥6100.00 S84859-50mg ￥6100.00 2-3天	0 貨期：2-3天	-	-	-

產品介紹

GW-1100 is a selective GPR40 antagonist with a pIC50 of 6.9.

產品描述：

GW-1100 is a selective GPR40 antagonist with a pIC50 of 6.9.

靶點：

pIC50: 6.9 (GPR40);GPR

體內研究：

The intracerebroventricular injection of DHA (50 μg) and GW9508 (1.0 μg), a GPR40-selective agonist, significantly reduces mechanical allodynia and thermal hyperalgesia at day 7, but not at day 1, after CFA injection. These effects are inhibited by intracerebroventricular pretreatment with GW-1100 (10 μg), a GPR40 antagonist

參考文獻：

1. Stoddart LA, et al. Uncovering the pharmacology of the G protein-coupled receptor GPR40: high apparent constitutive activity in guanosine 5'-O-(3-[35S]thio)triphosphate binding studies reflects binding of an endogenous agonist. Mol Pharmacol. 2007 Apr;71 2. Briscoe CP, et al. Pharmacological regulation of insulin secretion in MIN6 cells through the fatty acid receptor GPR40: identification of agonist and antagonist small molecules. Br J Pharmacol. 2006 Jul;148(5):619-28. 3. Manosalva C, et al. Cloning, identification and functional characterization of bovine free fatty acid receptor-1 (FFAR1/GPR40) in neutrophils. PLoS One. 2015 Mar 19;10(3):e0119715. 4. Nakamoto K, et al. Hypothalamic GPR40 signaling activated by free long chain fatty acids suppresses CFA-induced inflammatorychronic pain. PLoS One. 2013 Dec 12;8(12):e81563.

溶解性：

Soluble in DMSO

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	1.921 ml	9.604 ml	19.209 ml
5 mM	0.384 ml	1.921 ml	3.842 ml
10 mM	0.192 ml	0.96 ml	1.921 ml
50 mM	0.038 ml	0.192 ml	0.384 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

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