玖玖资源网站,爆乳久久久,日韩精品乱码久久久蜜桃,精品呦国产一区二区三区,国产伦高清一区二区三区,sese一区二区,午夜精品福利一区二区三区,三级黄色网站久久免费

產品中心

Product center

Bay 41-4109 98%

Bay 41-4109

源葉(MedMol)
S84823
298708-81-3
C18H13ClF3N3O2
395.7629
品牌 貨號 產品規格 價格(RMB) 庫存(上海) 北京 武漢 南京 購買數量
源葉(MedMol) S84823-1mg 98% ¥1200.00元 9 - - -
源葉(MedMol) S84823-5mg 98% ¥2600.00元 6 - - -
源葉(MedMol) S84823-10mg 98% ¥4600.00元 6 - - -
源葉(MedMol) S84823-50mg 98% ¥13000.00元 3 - - -
產品介紹 參考文獻 質檢證書(COA) 摩爾濃度計算器 相關產品

產品介紹

BAY 41-4109 is a potent inhibitor of human hepatitis B virus (HBV) with an IC50 of 53 nM
產品描述: BAY 41-4109 is a potent inhibitor of human hepatitis B virus (HBV) with an IC50 of 53 nM
靶點: IC50&Target: 53 nM (HBV);HBV
體外研究: BAY 41-4109 is able to both accelerate and misdirect capsid assembly in vitro. Preformed capsids are stabilized by BAY 41-4109, up to a ratio of one inhibitor molecule per two dimers. BAY 41-4109 is equally effective at inhibiting HBV DNA release and the cytoplasmic HBcAg level, with IC50s of 32.6 and 132 nM in HepG2.2.15 cells, respectively. HBV DNA and HBcAg are inhibited in a dose-dependent manner, indicating that the anti-HBV mechanisms are associated with and dependent on the rate of HBcAg inhibition
體內研究: BAY 41-4109 reduces viral DNA in the liver and in the plasma dose-dependently with efficacy comparable to 3TC. BAY 41 -4109 reduces hepatitis B virus core antigen (HBcAg) in livers of HBV-transgenic mice. Pharmacokinetic studies in mice have shown rapid absorption, a bioavailability of 30% and dose-proportional plasma concentrations, about 60% in rats and dogs.BAY41-4109 inhibits virus production in vivo by a mechanism that targets the viral capsid
參考文獻: 1. Weber O, et al. Inhibition of human hepatitis B virus (HBV) by a novel non-nucleosidic compound in a transgenic mouse model. Antiviral Res. 2002 May;54(2):69-78. 2. Stray SJ, et al. BAY 41-4109 has multiple effects on Hepatitis B virus capsid assembly. J Mol Recognit. 2006 Nov-Dec;19(6):542-8. 3. Wu GY, et al. Inhibition of hepatitis B virus replication by Bay 41-4109 and its association with nucleocapsid disassembly. J Chemother. 2008 Aug;20(4):458-67.
溶解性: Soluble  in  DMSO
保存條件: -20℃
配置溶液濃度參考:
1mg 5mg 10mg
1 mM 2.527 ml 12.634 ml 25.268 ml
5 mM 0.505 ml 2.527 ml 5.054 ml
10 mM 0.253 ml 1.263 ml 2.527 ml
50 mM 0.051 ml 0.253 ml 0.505 ml
注意: 部分產品我司僅能提供部分信息,我司不保證所提供信息的權威性,僅供客戶參考交流研究之用。

參考文獻

質檢證書(COA)

如何獲取質檢證書(COA)?
請輸入貨號和一個與之匹配的批號。
例如:
批號:JS298415 貨號:S20001-25g
在貨品標簽上如何找到貨號和批號?

摩爾濃度計算器

質量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)

=
×
×

相關產品

主站蜘蛛池模板: 昌吉市| 衢州市| 长武县| 长治市| 阜新市| 舒城县| 九台市| 大田县| 垦利县| 阿拉尔市| 苗栗市| 林口县| 嵩明县| 井冈山市| 澄城县| 宜君县| 温宿县| 河南省| 柳江县| 宣汉县| 泸溪县| 江达县| 濮阳县| 乳山市| 洛阳市| 明溪县| 太仆寺旗| 淄博市| 丽江市| 秀山| 江华| 长兴县| 漯河市| 木兰县| 冕宁县| 安丘市| 师宗县| 天峻县| 泾源县| 建始县| 济源市|