貨號	規格	價格	上海	北京	武漢	南京
S84805-2mg	99.8%	￥374.00 S84805-2mg ￥374.00 現貨	5 5	-	-	-
S84805-5mg	99.8%	￥697.00 S84805-5mg ￥697.00 現貨	6 6	-	-	-
S84805-10mg	99.8%	￥940.00 S84805-10mg ￥940.00 現貨	6 6	-	-	-
S84805-25mg	99.8%	￥1600.00 S84805-25mg ￥1600.00 現貨	5 5	-	-	-
S84805-50mg	99.8%	￥2390.00 S84805-50mg ￥2390.00 現貨	5 5	-	-	-
S84805-100mg	≥98%	￥3390.00 S84805-100mg ￥3390.00 2-3天	0 貨期：2-3天	-	-	-

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產品介紹

KY1220 is a compound that destabilizes both β-catenin and Ras, via targeting the Wnt/β-catenin pathway; with an IC50 of 2.1 μM in HEK293 reporter cells.

產品描述：

KY1220 is a compound that destabilizes both β-catenin and Ras, via targeting the Wnt/β-catenin pathway; with an IC50 of 2.1 μM in HEK293 reporter cells.

靶點：

IC50: 2.1 μM (HEK293 reporter cells);Wnt/beta-catenin

體外研究：

KY1220 shows an IC50 of 2.1 μM in HEK293 reporter cells. KY1220 dose dependently decreases Wnt3a-CM-induced TOPflash reporter activation and mRNA expression of Wnt target genes CCND1 and MYC in HEK293 cells. In HEK293 cells, both β-catenin and panRas protein levels are similarly reduced in a dose-dependent manner after treatment with KY1220, whereas the mRNA levels of CTNNB1 (which encodes β-catenin), NRAS, KRAS and HRAS remain unchanged. K-Ras, which has a critical role in progression of CRCs, is also destabilized by KY1220 via polyubiquitin-dependent proteasomal degradation. KY1220 accelerates the degradation rates of both β-catenin and Ras in SW480 cell lines. Ras destabilization by KY1220 consequently inhibits the activities of both ERK and Akt, which are downstream effectors of Ras in SW480 cells harboring a KRAS mutation. The proliferation and transformation of the HCT15, SW480, D-WT and D-MT CRC cells are efficiently inhibited after treatment with KY1220

參考文獻：

1. Cha PH, et al. Small-molecule binding of the axin RGS domain promotes β-catenin and Ras degradation. Nat Chem Biol. 2016 Aug;12(8):593-600.

溶解性：

Soluble in DMSO

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	3.181 ml	15.907 ml	31.815 ml
5 mM	0.636 ml	3.181 ml	6.363 ml
10 mM	0.318 ml	1.591 ml	3.181 ml
50 mM	0.064 ml	0.318 ml	0.636 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

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