貨號	規格	價格	上海	北京	武漢	南京
S84802-2mg	≥99%	￥340.00 S84802-2mg ￥340.00 2-3天	0 貨期：2-3天	-	-	-
S84802-5mg	99.7%	￥460.00 S84802-5mg ￥460.00 現貨	11 >10	-	-	-
S84802-10mg	99.7%	￥630.00 S84802-10mg ￥630.00 現貨	1 1	-	-	-
S84802-25mg	≥99%	￥1200.00 S84802-25mg ￥1200.00 2-3天	0 貨期：2-3天	-	-	-
S84802-50mg	≥99%	￥1800.00 S84802-50mg ￥1800.00 2-3天	0 貨期：2-3天	-	-	-

大包裝詢價收藏產品

加入購物車

產品介紹

Roflumilast N-oxide is a PDE type 4 inhibitor.

產品描述：

Roflumilast N-oxide is a PDE type 4 inhibitor.

靶點：

PDE type 4;PDE

體內研究：

Single treatment of db/db mice with 10 mg/kg Roflumilast N-oxide enhances plasma glucagon-like peptide-1 (GLP-1) 4-fold. Chronic treatment of db/db mice with Roflumilast N-oxide at 3 mg/kg shows prevention of disease progression. Roflumilast-N-oxide abolishes the increase in blood glucose, reduces the increment in HbA1c by 50% and doubles fasted serum insulin compare with vehicle, concomitants with preservation of pancreatic islet morphology. Furthermore, Roflumilast-N-oxide amplifies forskolin-induced insulin release in primary islets. Roflumilast-N-oxide also shows stronger glucose-lowering effects than its parent compound

參考文獻：

1. Victoni T, et al. Roflumilast n-oxide associated with PGE2 prevents the neutrophil elastase-induced production of chemokines by epithelial cells. Int Immunopharmacol. 2016 Jan;30:1-8. 2. Milara J,et al. Simvastatin Increases the Ability of Roflumilast N-oxide to Inhibit Cigarette Smoke-Induced Epithelial to Mesenchymal Transition in Well-differentiated Human Bronchial Epithelial Cells in vitro. COPD. 2015 Jun;12(3):320-31. 3. Vollert S, et al. The glucose-lowering effects of the PDE4 inhibitors roflumilast and roflumilast-N-oxide in db/db mice. Diabetologia. 2012 Oct;55(10):2779-2788.

溶解性：

Soluble in DMSO

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.385 ml	11.927 ml	23.854 ml
5 mM	0.477 ml	2.385 ml	4.771 ml
10 mM	0.239 ml	1.193 ml	2.385 ml
50 mM	0.048 ml	0.239 ml	0.477 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

質檢證書(COA)

輸入產品批號：

如何獲取質檢證書(COA)?

請輸入貨號和一個與之匹配的批號。
例如:
批號：JS298415 貨號：S20001-25g
在貨品標簽上如何找到貨號和批號?

摩爾濃度計算器

質量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)

質量

濃度

體積

分子摩爾量

計算重置

玖玖资源网站,爆乳久久久,日韩精品乱码久久久蜜桃,精品呦国产一区二区三区,国产伦高清一区二区三区,sese一区二区,午夜精品福利一区二区三区,三级黄色网站久久免费

Roflumilast N-Oxide