貨號	規(guī)格	價格	上海	北京	武漢	南京
S84797-5mg	≥98%(HPLC)	￥621.00 S84797-5mg ￥621.00 現(xiàn)貨	3 3	-	-	-
S84797-10mg	≥98%(HPLC)	￥1181.00 S84797-10mg ￥1181.00 現(xiàn)貨	4 4	-	-	-
S84797-25mg	≥98%(HPLC)	￥2700.00 S84797-25mg ￥2700.00 現(xiàn)貨	2 2	-	-	-
S84797-50mg	≥98%(HPLC)	￥4463.00 S84797-50mg ￥4463.00 現(xiàn)貨	1 1	-	-	-
S84797-100mg	≥98%(HPLC)	￥8800.00 S84797-100mg ￥8800.00 現(xiàn)貨	1 1	-	-	-

產(chǎn)品介紹

BMS 299897 is a sulfonamide γ-secretase inhibitor with an IC50 of 7 nM for Aβ production inhibition in HEK293 cells stably overexpressing amyloid precursor protein (APP).

產(chǎn)品描述：

BMS 299897 is a sulfonamide γ-secretase inhibitor with an IC50 of 7 nM for Aβ production inhibition in HEK293 cells stably overexpressing amyloid precursor protein (APP).

靶點：

IC50: 7 nM (Aβ, in HEK293 cells);BetaAmyloid;Gamma-secretase

體內(nèi)研究：

BMS-299897 shows dose- and time-dependent reductions of amyloid β-peptide (Aβ) in brain, cerebrospinal fluid (CSF), and plasma in young transgenic mice, with a correlation between brain and CSF Aβ levels. BMS-299897 reduces both brain and plasma Aβ1-40?in APP-YAC mice and increases brain concentrations of APPcarboxy-terminal fragments, consistent with γ-secretase inhibition. BMS-299897, attenuates this Aβ25-35-induced Aβ1-42?seeding and toxicity. BMS-299897 is administered at 0.1-1 nmol/mouse, concomittantly with Aβ25-35?(9 nmol) in male Swiss mice. After one week, the contents in Aβ1-42?and Aβ1-40, and the levels in lipid peroxidation are analyzed in the mouse hippocampus. Mice are submitted to spontaneous alternation, passive avoidance and object recognition to analyze their short- and long-term memory abilities. Aβ25-35?increases Aβ1-42?content (+240%) but fails to affect Aβ1-40. BMS-299897 blocks the increase in Aβ1-42?content and decreased Aβ1-40?levels significantly. The compound does not affect Aβ25-35-induced increase in hippocampal lipid peroxidation. Behaviorally, BMS-299897 blocks the Aβ25-35-induced deficits in spontaneous alternation or novel object recognition, using a 1 h intertrial time interval. The co-administration of the γ-secretase inhibitor BMS-299897, in the 0.1-1 μmol/mouse dose-range, completely blocks the Aβ25-35-induced increase in Aβ1-42?content

參考文獻：

1. Meunier J, et al. The γ-secretase inhibitor 2-[(1R)-1-[(4-chlorophenyl)sulfonyl](2,5-difluorophenyl) amino]ethyl-5-fluorobenzenebutanoic acid (BMS-299897) alleviates Aβ1-42 seeding and short-term memory deficits in the Aβ25-35 mouse model of Alzheimer's d 2. Weissmiller AM, et al. A γ-secretase inhibitor, but not a γ-secretase modulator, induced defects in BDNF axonal trafficking and signaling: evidence for a role for APP. PLoS One. 2015 Feb 24;10(2):e0118379.

溶解性：

Soluble in DMSO

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	1.953 ml	9.767 ml	19.534 ml
5 mM	0.391 ml	1.953 ml	3.907 ml
10 mM	0.195 ml	0.977 ml	1.953 ml
50 mM	0.039 ml	0.195 ml	0.391 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻

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