貨號	規格	價格	上海	北京	武漢	南京
S84720-5mg	97.1%	￥460.00 S84720-5mg ￥460.00 現貨	10 10	-	-	-
S84720-10mg	97.1%	￥630.00 S84720-10mg ￥630.00 現貨	7 7	-	-	-
S84720-25mg	97.1%	￥1000.00 S84720-25mg ￥1000.00 現貨	4 4	-	-	-
S84720-50mg	≥97%	￥1470.00 S84720-50mg ￥1470.00 2-3天	0 貨期：2-3天	-	-	-
S84720-100mg	≥97%	￥2200.00 S84720-100mg ￥2200.00 2-3天	0 貨期：2-3天	-	-	-

大包裝詢價收藏產品

加入購物車

產品介紹

SD 0006 (SD-06) is an orally active, selective, ATP-competitive and potent diaryl pyrazole inhibitor of p38α MAP kinase, with an IC50 of 110 nM for p38α

產品描述：

SD 0006 (SD-06) is an orally active, selective, ATP-competitive and potent diaryl pyrazole inhibitor of p38α MAP kinase, with an IC50 of 110 nM for p38α

靶點：

IC50: 110 nM (p38 MAPK);p38MAPK;Autophagy

體外研究：

SD 0006 clearly inhibits p38α as shown by the dose-dependent inhibition of phosphorylation of its endogenous Hsp27 substrate

體內研究：

SD 0006 (0-30 mg/kg) may be an effective alternative to steroids and biologics for RA therapy. SD0006 (3.75, 7.5 and 15 mg/kg; p.o.; b.i.d.) is highly effective in attenuating SCW-induced inflammation as shown by the dose-dependent inhibition of paw swelling. Animal Model: 8- to 12-week-old DBA/1 mice. Dosage: 3.75, 7.5 and 15 mg/kg. Administration: Orally twice daily. Result: Inhibited the transcription of several inflammatory mediators to prevent joint swelling and bone destruction and to preserve bone density.

參考文獻：

1. Burnette BL, et al. SD0006: a potent, selective and orally available inhibitor of p38 kinase. Pharmacology. 2009;84(1):42-60. 2. Walker JK, et al. Identification of SD-0006, a potent diaryl pyrazole inhibitor of p38 MAP kinase. Bioorg Med Chem Lett. 2010 Apr 15;20(8):2634-8.

溶解性：

Soluble in DMSO

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.513 ml	12.567 ml	25.135 ml
5 mM	0.503 ml	2.513 ml	5.027 ml
10 mM	0.251 ml	1.257 ml	2.513 ml
50 mM	0.05 ml	0.251 ml	0.503 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

質檢證書(COA)

輸入產品批號：

如何獲取質檢證書(COA)?

請輸入貨號和一個與之匹配的批號。
例如:
批號：JS298415 貨號：S20001-25g
在貨品標簽上如何找到貨號和批號?

摩爾濃度計算器

質量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)

質量

濃度

體積

分子摩爾量

計算重置

玖玖资源网站,爆乳久久久,日韩精品乱码久久久蜜桃,精品呦国产一区二区三区,国产伦高清一区二区三区,sese一区二区,午夜精品福利一区二区三区,三级黄色网站久久免费