貨號	規格	價格	上海	北京	武漢	南京
S84628-5mg	99.7%	￥150.00 S84628-5mg ￥150.00 現貨	5 5	-	-	-
S84628-10mg	99.7%	￥235.00 S84628-10mg ￥235.00 現貨	7 7	-	-	-
S84628-25mg	99.7%	￥540.00 S84628-25mg ￥540.00 現貨	6 6	-	-	-
S84628-50mg	99.7%	￥1997.00 S84628-50mg ￥1997.00 現貨	5 5	-	-	-

產品介紹

Leonurine hydrochloride is an alkaloid isolated from Leonurus artemisia, with anti-oxidative and anti-inflammatory.

產品描述：

Leonurine hydrochloride is an alkaloid isolated from Leonurus artemisia, with anti-oxidative and anti-inflammatory.

靶點：

Autophagy;TLR;?Autophagy

體內研究：

Leonurine (10 mg/kg/d, p.o.) significantly increases the expressions of PPARγ, LXRα, ABCA1 and ABCG1, and decreases both TG and TC levels in serum of mice. Leonurine hydrochloride (50, 100, 200 mg/kg) improves intracellular lipid accumulation via activating AMPK/SREBP1 pathway, enhances biochemical parameters, reduces hepatic lipoperoxide and increases antioxidant levels in mice. Leonurine (20?mg/kg, p.o.) ameliorates osteoarthritis development in mouse DMM model

參考文獻：

1. Jiang T, et al. Leonurine Prevents Atherosclerosis Via Promoting the Expression of ABCA1 and ABCG1 in a Pparγ/Lxrα Signaling Pathway-Dependent Manner. Cell Physiol Biochem. 2017;43(4):1703-1717. 2. Zhang L, et al. Novel hepatoprotective role of Leonurine hydrochloride against experimental non-alcoholic steatohepatitis mediated via AMPK/SREBP1 signaling pathway. Biomed Pharmacother. 2018 Dec 7;110:571-581. 3. Hu ZC, et al. Inhibition of PI3K/Akt/NF-κB signaling with leonurine for ameliorating the progression of osteoarthritis: In vitro and in vivo studies. J Cell Physiol. 2018 Nov 11.

溶解性：

DMSO : ≥ 31 mg/mL (89.13 mM) H2O : 5 mg/mL (14.38 mM; Need ultrasonic)

保存條件：

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.875 ml	14.376 ml	28.752 ml
5 mM	0.575 ml	2.875 ml	5.75 ml
10 mM	0.288 ml	1.438 ml	2.875 ml
50 mM	0.058 ml	0.288 ml	0.575 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

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摩爾濃度計算器

質量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)

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分子摩爾量

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Leonurine hydrochloride

4-(diaminomethylideneamino)butyl 4-hydroxy-3,5-dimethoxybenzoate,hydrochloride