貨號	規格	價格	上海	北京	武漢	南京
S84619-5mg	99.0%	￥430.00 S84619-5mg ￥430.00 現貨	8 8	-	-	-
S84619-10mg	99.0%	￥640.00 S84619-10mg ￥640.00 現貨	7 7	-	-	-
S84619-50mg	99.0%	￥1600.00 S84619-50mg ￥1600.00 現貨	3 3	-	-	-

產品介紹

Pyr6 is a selective TRPC3 inhibitor with IC50 of 0.49 uM(Ca2+ influx inhibition in thapsigargin depleted native RBL-2H3 cells).Pyr6 is an inhibitor of Ca2+ entry, which displays higher potency to inhibit Ca2+ entry mediated by CRAC channel than by TRPC3.

產品描述：

靶點：

TRP/TRPV Channel;TRP/TRPVChannel

體外研究：

Pyr3 is selective inhibitor of TRPC3, inhibited Orai1- and TRPC3-mediated Ca(2+) entry and currents as well as mast cell activation with similar potency.By contrast, Pyr6 exhibited a 37-fold higher potency to inhibit Orai1-mediated Ca(2+) entry as compared with TRPC3-mediated Ca(2+) entry and potently suppressed mast cell activation.

參考文獻：

1. Schleifer H, et al. Novel pyrazole compounds for pharmacological discrimination between receptor-operated and store-operated Ca(2+) entry pathways. Br J Pharmacol. 2012 Dec;167(8):1712-22.

溶解性：

Soluble in DMSO

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.391 ml	11.954 ml	23.908 ml
5 mM	0.478 ml	2.391 ml	4.782 ml
10 mM	0.239 ml	1.195 ml	2.391 ml
50 mM	0.048 ml	0.239 ml	0.478 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

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質量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)

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