貨號	規格	價格	上海	北京	武漢	南京
S84594-25mg	98.2%	￥460.00 S84594-25mg ￥460.00 現貨	10 10	-	-	-
S84594-100mg	98.2%	￥840.00 S84594-100mg ￥840.00 現貨	6 6	-	-	-
S84594-1g	98.2%	￥2800.00 S84594-1g ￥2800.00 現貨	4 0 4	-	-	-

產品介紹

DNQX (FG 9041), a quinoxaline derivative, is a selective, potent competitive non-NMDA glutamate receptor antagonist (IC50s = 0.5, 2 and 40 μM for AMPA, kainate and NMDA receptors, respectively)

產品描述：

DNQX (FG 9041), a quinoxaline derivative, is a selective, potent competitive non-NMDA glutamate receptor antagonist (IC50s = 0.5, 2 and 40 μM for AMPA, kainate and NMDA receptors, respectively)

靶點：

AMPA Receptor;Kainate Receptor;GluR;?iGluR

體內研究：

DNQX, a specific AMPA receptor antagonist, given as either a 5 mg/kg or 10 mg/kg intraperitoneal dose or into the lateral cerebral ventricle (5 μl of 0.5 mg/ml) significantly diminishes phencyclidine (PCP) (40 mg/kg) and ketamine (80, 100, 120 mg/kg) hsp70 induction in the posterior cingulate and retrosplenial cortex

參考文獻：

1. Honoré T, et al. Quinoxalinediones: potent competitive non-NMDA glutamate receptor antagonists. Science. 1988;241(4866):701-703. 2. Lee SH, et al. Selective excitatory actions of DNQX and CNQX in rat thalamic neurons. J Neurophysiol. 2010;103(4):1728-1734. 3. Sharp JW, et al. DNQX inhibits phencyclidine (PCP) and ketamine induction of the hsp70 heat shock gene in the rat cingulate and retrosplenial cortex. Brain Res. 1995;687(1-2):114-124.

溶解性：

DMSO : ≥ 35 mg/mL (138.81 mM) H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble)

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	3.966 ml	19.83 ml	39.661 ml
5 mM	0.793 ml	3.966 ml	7.932 ml
10 mM	0.397 ml	1.983 ml	3.966 ml
50 mM	0.079 ml	0.397 ml	0.793 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

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