貨號(hào)	規(guī)格	價(jià)格	上海	北京	武漢	南京
S84509-5mg	≥98%	￥500.00 S84509-5mg ￥500.00 2-3天	0 貨期：2-3天	-	-	-
S84509-10mg	≥98%	￥700.00 S84509-10mg ￥700.00 2-3天	0 貨期：2-3天	-	-	-
S84509-50mg	≥98%	￥2400.00 S84509-50mg ￥2400.00 2-3天	0 貨期：2-3天	-	-	-

產(chǎn)品介紹

Garenoxacin (BMS284756) Mesylate hydrate is an orally active quinolone antibiotic and has a broad spectrum of activity against a wide array of gram-positive and gram-negative bacteria, anaerobes, and fastidious organisms

產(chǎn)品描述：

靶點(diǎn)：

Quinolone;Gyrase:1.25 μg/mL (IC50);TOPO IV:1.5-2.5 μg/mL (IC50);Antibacterial

體內(nèi)研究：

Garenoxacin (12.5-50 mg/kg; s.c.; once) is highly effective against the wild-type strain and mutants harboring a single mutation in a mouse pneumonia model with S. pneumonia infection. Garenoxacin (10 and 30 mg/kg; p.o.; once) reduces the viable cell counts in the lungs and significantly prolongs survival on experimental secondary pneumococcal pneumonia caused by S. pneumoniae D-979 in BALB/c female mice Animal Model: Swiss mice with S. pneumonia infection. Dosage: 12.5, 25 and 50 mg/kg Administration: Subcutaneous injection, once Result: Significantly improved the survival rate.

參考文獻(xiàn)：

1. Waites KB, et al. In vitro susceptibilities to and bactericidal activities of garenoxacin (BMS-284756) and other antimicrobial agents against human mycoplasmas and ureaplasmas. Antimicrob Agents Chemother. 2003 Jan;47(1):161-5. 2. Ince D, et al. Dual targeting of DNA gyrase and topoisomerase IV: target interactions of garenoxacin (BMS-284756, T-3811ME), a new desfluoroquinolone. Antimicrob Agents Chemother. 2002 Nov;46(11):3370-80. 3. Zhao X, et al. Mutant prevention concentration of garenoxacin (BMS-284756) for ciprofloxacin-susceptible or -resistant Staphylococcus aureus. Antimicrob Agents Chemother. 2003 Mar;47(3):1023-7. [Content Brief] 4. Azoulay-Dupuis E, et al. Activities of garenoxacin against quinolone-resistant Streptococcus pneumoniae strains in vitro and in a mouse pneumonia model. Antimicrob Agents Chemother. 2004 Mar;48(3):765-73. 5. Fukuda Y, et al. Therapeutic effects of garenoxacin in murine experimental secondary pneumonia by Streptococcus pneumoniae after influenza virus infection. Diagn Microbiol Infect Dis. 2014 Feb;78(2):168-71.

溶解性：

Soluble in DMSO、H2O

保存條件：

2-8℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	1.85 ml	9.25 ml	18.5 ml
5 mM	0.37 ml	1.85 ml	3.7 ml
10 mM	0.185 ml	0.925 ml	1.85 ml
50 mM	0.037 ml	0.185 ml	0.37 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻(xiàn)

質(zhì)檢證書(COA)

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批號(hào)：JS298415 貨號(hào)：S20001-25g
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