| 產品描述： | CX546 is a first-generation and selective benzamide-type positive AMPAR modulator. CX546 is a prototypical ampakine agent and has antipsychotic effects |
| 靶點： |
AMPA Receptor;Autophagy;?iGluR |
| 體內研究： |
Treatment with the ampakine CX614 (intraperitoneal injection) markedly and reversibly increase brain-derived neurotrophic factor (BDNF) mRNA and protein levels in cultured rat entorhinal/hippocampal slices |
| 參考文獻： |
1. Lauterborn JC, et al. Positive modulation of AMPA receptors increases neurotrophin expression by hippocampal and cortical neurons. J Neurosci. 2000 Jan 1;20(1):8-21. 2. Lipina T, et al. The ampakine CX546 restores the prepulse inhibition and latent inhibition deficits in mGluR5-deficient mice. Neuropsychopharmacology. 2007 Apr;32(4):745-56. |
| 溶解性： |
DMSO : 100 mg/mL (404.38 mM; Need ultrasonic) Ethanol : 100 mg/mL (404.38 mM; Need ultrasonic) H2O : 2 mg/mL (8.09 mM; Need ultrasonic) |
| 保存條件： |
2-8℃ |
| 配置溶液濃度參考： |
|
1mg |
5mg |
10mg |
| 1 mM |
4.044 ml |
20.219 ml |
40.438 ml |
| 5 mM |
0.809 ml |
4.044 ml |
8.088 ml |
| 10 mM |
0.404 ml |
2.022 ml |
4.044 ml |
| 50 mM |
0.081 ml |
0.404 ml |
0.809 ml |
|
| 注意： |
部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。 |
上海工商
危險品化學品經營許可證（不帶存儲）
營業執照(三證合一)
北京