貨號	規格	價格	上海	北京	武漢	南京
S84399-2mg	98.1%	￥200.00 S84399-2mg ￥200.00 現貨	5 5	-	-	-
S84399-5mg	98.1%	￥330.00 S84399-5mg ￥330.00 現貨	6 6	-	-	-
S84399-10mg	98.1%	￥440.00 S84399-10mg ￥440.00 現貨	6 6	-	-	-
S84399-25mg	98.1%	￥590.00 S84399-25mg ￥590.00 現貨	5 5	-	-	-
S84399-50mg	≥98%	￥1020.00 S84399-50mg ￥1020.00 2-3天	0 貨期：2-3天	-	-	-
S84399-100mg	≥98%	￥2000.00 S84399-100mg ￥2000.00 2-3天	0 貨期：2-3天	-	-	-

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產品介紹

Farampator (CX-691;Org24448) is a positive modulator of AMPA receptor.

產品描述：

Farampator (CX-691;Org24448) is a positive modulator of AMPA receptor.

靶點：

GluR;iGluR;GluR;?iGluR

體內研究：

Farampator has potential in treating disorders characterised by cognitive deficits such as Alzheimer's disease and schizophrenia. CX691 attenuates a scopolamine-induced impairment of cued fear conditioning following acute administration (0.1 mg/kg p.o.) and a temporally induced deficit in novel object recognition following both acute (0.1 and 1.0 mg/kg p.o.) and sub-chronic (bi-daily for 7 days) administration (0.01, 0.03, 0.1 mg/kg p.o.). It also improves attentional set-shifting following sub-chronic administration (0.3 mg/kg p.o.)[1]. Farampator (500 mg) unequivocally improves short-term memory but appeares to impair episodic memory. Besides, it tends to decrease the number of switching errors in the CTMT. Drug-induced side effects (SEs) included headache, somnolence and nausea. Subjects with SEs has significantly higher plasma levels of farampator than subjects without SEs

參考文獻：

1.Woolley ML, et al. Evaluation of the pro-cognitive effects of the AMPA receptor positive modulator, 5-(1-piperidinylcarbonyl)-2,1,3-benzoxadiazole (CX691), in the rat. Psychopharmacology (Berl). 2009 Jan;202(1-3):343-54. 2.Wezenberg E, et al. Acute effects of the ampakine farampator on memory and information processing in healthy elderly volunteers. Neuropsychopharmacology. 2007 Jun;32(6):1272-83.

溶解性：

DMSO:34 mg/mL

保存條件：

2-8℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	4.324 ml	21.622 ml	43.243 ml
5 mM	0.865 ml	4.324 ml	8.649 ml
10 mM	0.432 ml	2.162 ml	4.324 ml
50 mM	0.086 ml	0.432 ml	0.865 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

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