貨號	規格	價格	上海	北京	武漢	南京
S84342-100mg	99.7%	￥285.00 S84342-100mg ￥285.00 現貨	13 >10	-	-	-
S84342-500mg	99.7%	￥670.00 S84342-500mg ￥670.00 現貨	5 5	-	-	-
S84342-2.5g	≥99%	￥3060.00 S84342-2.5g ￥3060.00 2-3天	0 貨期：2-3天	-	-	-

產品介紹

Tacrine hydrochloride (hydrate) is an inhibitor of both acetyl (AChE) and butyryl-cholinestrase (BChE) with IC50s of 31 nM and 25.6 nM, respectively.

產品描述：

Tacrine hydrochloride (hydrate) is an inhibitor of both acetyl (AChE) and butyryl-cholinestrase (BChE) with IC50s of 31 nM and 25.6 nM, respectively.

靶點：

IC50: 31 nM (AChE), 25.6 nM (BChE);AChR;?AChE

體內研究：

Pretreatment with Tacrine hydrochloride (hydrate) also modifies absolute levels of cocaine self-administration during reacquisition. Body weight declines approximately one-half percent over four days of treatment with intravenous Tacrine hydrochloride (hydrate). Delivery of Tacrine hydrochloride (hydrate) by osmotic pump does not alter either linear- or repeated- cocaine-induced locomotor activity. There is no significant main effect or interaction with Tacrine hydrochloride (hydrate) treatment on active lever responding during reinstatement. Post hoc comparisons indicate that rats self-administering cocaine has significantly lower alkaline phosphatase levels, relative to TTacrine hydrochloride (hydrate)- but not saline- treated rats evaluated by conditioned-place preference

參考文獻：

1. Ahmed M, et al. Inhibition of two different cholinesterases by tacrine. Chem Biol Interact. 2006 Aug 25;162(2):165-71. 2. Grasing K, et al. Enduring effects of tacrine on cocaine-reinforced behavior: Analysis by conditioned-place preference, temporal separation from drug reward, and reinstatement. Pharmacol Res. 2015 Jul;97:40-7.

溶解性：

H2O : 100 mg/mL (Need ultrasonic) DMSO : 32 mg/mL (Need ultrasonic and warming)

保存條件：

2-8℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	3.957 ml	19.783 ml	39.566 ml
5 mM	0.791 ml	3.957 ml	7.913 ml
10 mM	0.396 ml	1.978 ml	3.957 ml
50 mM	0.079 ml	0.396 ml	0.791 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

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摩爾濃度計算器

質量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)

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Tacrine HCl hydrate