貨號	規(guī)格	價格	上海	北京	武漢	南京
S84308-2mg	≥98%	￥1100.00 S84308-2mg ￥1100.00 2-3天	0 貨期：2-3天	-	-	-
S84308-5mg	≥98%	￥1900.00 S84308-5mg ￥1900.00 2-3天	0 貨期：2-3天	-	-	-
S84308-10mg	≥98%	￥2800.00 S84308-10mg ￥2800.00 2-3天	0 貨期：2-3天	-	-	-
S84308-25mg	≥98%	￥5800.00 S84308-25mg ￥5800.00 2-3天	0 貨期：2-3天	-	-	-

大包裝詢價收藏產品

加入購物車

到貨通知，提交手機號入庫后將短信通知。

產品介紹

AX-15836 is a potent and selective ERK5 inhibitor with an IC50 of 8 nM.

產品描述：

AX-15836 is a potent and selective ERK5 inhibitor with an IC50 of 8 nM.

靶點：

ERK5:8 nM (IC50);ERK

體外研究：

AX-15836 shows more than 1,000-fold selectivity for ERK5 over a panel of over 200 kinases. It also exhibits selectivity over BRD4 with a Kd of 3,600 nM. AX15836 shows similar intracellular potency (4–9 nM) across all cells tested, including peripheral blood mononuclear cells (PBMCs), endothelial cells, and oncogenic cell lines. AX15836 was completely ineffective (EC50>10 μM) to suppress inflammatory cytokine response, suggesting that it was the BRD inhibition component of the compounds that mediated cytokine reduction. In HUVEC and HeLa cell types, samples treated with AX15836 shows very few genes to be differentially expressed. AX15836 could clearly inhibit the EGF-stimulated, phosphorylated form of ERK5 in HeLa cells

參考文獻：

1. Lin EC, et al. ERK5 kinase activity is dispensable for cellular immune response and proliferation. Proc Natl Acad Sci U S A. 2016 Oct 18;113(42):11865-11870.

溶解性：

Soluble in DMSO

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	1.541 ml	7.707 ml	15.414 ml
5 mM	0.308 ml	1.541 ml	3.083 ml
10 mM	0.154 ml	0.771 ml	1.541 ml
50 mM	0.031 ml	0.154 ml	0.308 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

質檢證書(COA)

輸入產品批號：

如何獲取質檢證書(COA)?

請輸入貨號和一個與之匹配的批號。
例如:
批號：JS298415 貨號：S20001-25g
在貨品標簽上如何找到貨號和批號?

摩爾濃度計算器

質量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)

質量

濃度

體積

分子摩爾量

計算重置

玖玖资源网站,爆乳久久久,日韩精品乱码久久久蜜桃,精品呦国产一区二区三区,国产伦高清一区二区三区,sese一区二区,午夜精品福利一区二区三区,三级黄色网站久久免费