貨號	規格	價格	上海	北京	武漢	南京
S84126-2mg	99.1%	￥180.00 S84126-2mg ￥180.00 現貨	14 >10	-	-	-
S84126-5mg	99.1%	￥300.00 S84126-5mg ￥300.00 現貨	18 >10	-	-	-
S84126-10mg	99.1%	￥450.00 S84126-10mg ￥450.00 現貨	10 10	-	-	-
S84126-25mg	99.1%	￥560.00 S84126-25mg ￥560.00 現貨	3 3	-	-	-
S84126-100mg	99.1%	￥1380.00 S84126-100mg ￥1380.00 現貨	2 2	-	-	-

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產品介紹

SC-560 is a potent and selective COX-1 inhibitor with an IC50 of 9 nM.

產品描述：

SC-560 is a potent and selective COX-1 inhibitor with an IC50 of 9 nM.

靶點：

COX-1：9 nM (IC50)；COX-2：6.3 μM (IC50);COX

體內研究：

Oral dosing with either 10 or 30 mg/kg SC-560 1 hour before assay completely inhibits ionophore-stimulated TxB2production, indicating that SC-560 is orally bioavailable and inhibits COX-1 in vivo. SC-560 extensively distributes into rat tissues, and has a CL approaching hepatic plasma flow. The drug displays low less than 15% and formulation dependent bioavailability after oral administration and demonstrates kidney toxicity

參考文獻：

1. Smith CJ, et al. Pharmacological analysis of cyclooxygenase-1 in inflammation. Proc Natl Acad Sci U S A. 1998 Oct 27;95(22):13313-8. 2. Lampiasi N, et al. The selective cyclooxygenase-1 inhibitor SC-560 suppresses cell proliferation and induces apoptosis in human hepatocellular carcinoma cells. Int J Mol Med. 2006 Feb;17(2):245-52. 3. Teng XW, et al. Formulation dependent pharmacokinetics, bioavailability and renal toxicity of a selective cyclooxygenase-1 inhibitor SC-560 in the rat. J Pharm Pharm Sci. 2003 May-Aug;6(2):205-10.

溶解性：

DMSO : 100 mg/mL (283.49 mM; Need ultrasonic)

保存條件：

2-8℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.835 ml	14.175 ml	28.349 ml
5 mM	0.567 ml	2.835 ml	5.67 ml
10 mM	0.283 ml	1.417 ml	2.835 ml
50 mM	0.057 ml	0.283 ml	0.567 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

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