貨號	規(guī)格	價格	上海	北京	武漢	南京
S84091-1mg	≥98%	￥1100.00 S84091-1mg ￥1100.00 2-3天	0 貨期：2-3天	-	-	-
S84091-5mg	≥98%	￥2400.00 S84091-5mg ￥2400.00 2-3天	0 貨期：2-3天	-	-	-
S84091-10mg	≥98%	￥4200.00 S84091-10mg ￥4200.00 2-3天	0 貨期：2-3天	-	-	-

產(chǎn)品介紹

MI-538 is an inhibitor of the interaction between menin and MLL fusion proteins with an IC50 of 21 nM

產(chǎn)品描述：

MI-538 is an inhibitor of the interaction between menin and MLL fusion proteins with an IC50 of 21 nM

靶點：

IC50 : 21 nM (menin and MLL interaction); Kd: 6.5 nM (menin);EpigeneticReaderDomain;?HistoneMethyltransferase

體外研究：

MI-538 inhibits the proliferation of MLL leukemia cells with a GI50 of 83 nM. MI-538 shows no effect (up to 6 μM) on growth of the control cell lines HL-60 and HM-2, which do not harbor MLL translocations, demonstrating good selectivity toward MLL fusion protein transformed cells. MI-538 binds to menin with low nanomolar affinity (Kd=6.5 nM). Its potent cellular activity originates from the improved binding affinity to menin and possibly increased cell membrane permeability. Treatment with MI-538 results in strong down regulation of expression of Hoxa9 and Meis1 genes. About 100 nM 27 was sufficient to reduce by ~50% Hoxa9 expression in MLL-AF9 cells, and even more pronounced effect was seen on Meis1 expression

體內(nèi)研究：

Treatment with MI-538 results in a pronounced, about 80%, reduction in the MV4;11 tumor volume, without causing substantial signs of toxicity reflected by less than 10% reduction of the body weight. MI-538 demonstrates markedly improved exposure (area under the curve, AUC, values), Cmax (maximum compound concentration) in the blood plasma, and the lowest value of clearance. The half-life of MI-538 is about 1.6 h. MI-538 has also high oral bioavailability (~50%)

參考文獻：

1. Borkin D, et al. Property Focused Structure-Based Optimization of Small Molecule Inhibitors of the Protein-Protein Interaction between Menin and Mixed Lineage Leukemia (MLL). J Med Chem. 2016 Feb 11;59(3):892-913.

溶解性：

soluble in DMSO

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	1.765 ml	8.825 ml	17.649 ml
5 mM	0.353 ml	1.765 ml	3.53 ml
10 mM	0.176 ml	0.882 ml	1.765 ml
50 mM	0.035 ml	0.176 ml	0.353 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻

質(zhì)檢證書(COA)

輸入產(chǎn)品批號：

如何獲取質(zhì)檢證書(COA)?

請輸入貨號和一個與之匹配的批號。
例如:
批號：JS298415 貨號：S20001-25g
在貨品標簽上如何找到貨號和批號?

摩爾濃度計算器

質(zhì)量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)

質(zhì)量

濃度

體積

分子摩爾量

計算重置

玖玖资源网站,爆乳久久久,日韩精品乱码久久久蜜桃,精品呦国产一区二区三区,国产伦高清一区二区三区,sese一区二区,午夜精品福利一区二区三区,三级黄色网站久久免费