貨號	規格	價格	上海	北京	武漢	南京
S84060-1mg	≥99%	￥230.00 S84060-1mg ￥230.00 2-3天	0 貨期：2-3天	-	-	-
S84060-5mg	≥99%	￥495.00 S84060-5mg ￥495.00 2-3天	0 貨期：2-3天	-	-	-
S84060-10mg	≥99%	￥740.00 S84060-10mg ￥740.00 2-3天	0 貨期：2-3天	-	-	-
S84060-25mg	≥99%	￥1820.00 S84060-25mg ￥1820.00 2-3天	0 貨期：2-3天	-	-	-

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產品介紹

Ravuconazole (BMS-207147;ER-30346) is an orally available triazole antifungle agent that potently inhibits a wide range of fungi.

產品描述：

Ravuconazole (BMS-207147;ER-30346) is an orally available triazole antifungle agent that potently inhibits a wide range of fungi.

靶點：

Fungal;Antifungal

體內研究：

The maximum concentration of ravuconazole in plasma and the area under the concentration-time curve for ravuconazoleshow good linearity over a range of doses from 2 to 40 mg/kg of body weight. Ravuconazole at a dose of 2.5 mg/kg delays mortality significantly compared with the control treatment.Ravuconazole also shows a substantial therapeutic effect against systemic cryptococcosis. Ravuconazole reduces the numbers of CFU in the lungs significantly compared with the numbers of CFU in the lungs of the controls. In an experimental model of oral candidiasis in rats, ravuconazole reduces the numbers of CFU in oral swabs significantly compared with the numbers of CFU in oral swabs from the controls and is more effective than itraconazole and as effective as fluconazole.

參考文獻：

1. Hata K, et al. In vitro and in vivo antifungal activities of ER-30346, a novel oral triazole with a broad antifungal spectrum.Antimicrob Agents Chemother. 1996 Oct;40(10):2237-42. 2. Fung-Tomc JC, et al. In vitro activity of a new oral triazole, BMS-207147 (ER-30346)Antimicrob Agents Chemother. 1998 Feb;42(2):313-8. 3. Hata K, et al. Efficacy of ER-30346, a novel oral triazole antifungal agent, in experimental models of aspergillosis, candidiasis, and cryptococcosis.Antimicrob Agents Chemother. 1996 Oct;40(10):2243-7.

溶解性：

Soluble in DMSO

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.286 ml	11.429 ml	22.859 ml
5 mM	0.457 ml	2.286 ml	4.572 ml
10 mM	0.229 ml	1.143 ml	2.286 ml
50 mM	0.046 ml	0.229 ml	0.457 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

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摩爾濃度計算器

質量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)

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Ravuconazole (BMS-207147; ER-30346)

4-[2-[(2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-4-(1,2,4-triazol-1-yl)b utan-2-yl]-1,3-thiazol-4-yl]benzonitrile