貨號(hào)	規(guī)格	價(jià)格	上海	北京	武漢	南京	購買數(shù)量
S84057-5mg	≥98%	￥1100.00 S84057-5mg ￥1100.00 現(xiàn)貨	1 1	-	-	-
S84057-10mg	≥98%	￥1980.00 S84057-10mg ￥1980.00 2-3天	0 貨期：2-3天	-	-	-

產(chǎn)品介紹

Ribocil-C is a highly selective inhibitor of bacterial riboflavin riboswitches.

產(chǎn)品描述：

Ribocil-C is a highly selective inhibitor of bacterial riboflavin riboswitches.

靶點(diǎn)：

Bacterial riboflavin riboswitches;Antibacterial

體外研究：

Ribocil-C is a highly selective inhibitor of the flavin mononucleotide (FMN) riboswitch that controls expression of de novo riboflavin (RF, vitamin B2) biosynthesis in Escherichia coli. Ribocil-C specifically inhibits dual FMN riboswitches, separately controlling RF biosynthesis and uptake processes essential for Staphylococcus aureus growth and pathogenesis. Ribocil-C is a small-molecule synthetic mimic of FMN that binds the FMN riboswitch of multiple GN bacteria, including Escherichia coli, Pseudomonas aeruginosa, and Acinetobacter baumannii, to inhibit ribB expression, RF synthesis, and consequently arrest bacterial growth

體內(nèi)研究：

Higher dose Ribocil-C treatment groups (60 and 120 mg kg21 ribocil-C) demonstrate a dose-dependent reduction in bacterial burden of 1.87 and 3.29 log10[CFU per g spleen] reduction respectively versus shamtreated mice, without mortality or gross effects of toxicity observed

參考文獻(xiàn)：

1. Wang H, et al. Dual-Targeting Small-Molecule Inhibitors of the Staphylococcus aureus FMN Riboswitch DisruptRiboflavin Homeostasis in an Infectious Setting. Cell Chem Biol. 2017 May 18;24(5):576-588. 2. Howe JA, et al. Selective small-molecule inhibition of an RNA structural element. Nature. 2015 Oct 29;526(7575):672-7.

溶解性：

soluble in DMSO

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.384 ml	11.919 ml	23.838 ml
5 mM	0.477 ml	2.384 ml	4.768 ml
10 mM	0.238 ml	1.192 ml	2.384 ml
50 mM	0.048 ml	0.238 ml	0.477 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻(xiàn)

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