貨號(hào)	規(guī)格	價(jià)格	上海	北京	武漢	南京
S84032-1mg	≥99%	￥1500.00 S84032-1mg ￥1500.00 2-3天	0 貨期：2-3天	-	-	-
S84032-5mg	≥99%	￥3300.00 S84032-5mg ￥3300.00 2-3天	0 貨期：2-3天	-	-	-
S84032-10mg	≥99%	￥4800.00 S84032-10mg ￥4800.00 2-3天	0 貨期：2-3天	-	-	-
S84032-50mg	≥99%	￥14400.00 S84032-50mg ￥14400.00 2-3天	0 貨期：2-3天	-	-	-
S84032-100mg	≥99%	￥20100.00 S84032-100mg ￥20100.00 2-3天	0 貨期：2-3天	-	-	-

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產(chǎn)品介紹

EPZ031686 is an effective inhibitor of SMYD3 inhibitor with an IC50 of 3 nM and can be used in studies about cancer.

產(chǎn)品描述：

EPZ031686 is an effective inhibitor of SMYD3 inhibitor with an IC50 of 3 nM and can be used in studies about cancer.

靶點(diǎn)：

Histone Methyltransferase;HistoneMethyltransferase

體內(nèi)研究：

In male CD-1 mice, EPZ031686 (1 mg/kg; i.v.) shows a moderate clearance (CL) of 27 ± 3.9 mL/min/kg, in very good agreement with the mouse microsomal data, with a volume of distribution at steady state (Vss) of 2.3 ± 0.29 L/kg, translating to a mean terminal half-life (t1/2) of 1.7 ± 0.13 h. After the treatment of EPZ031686 (5 and 50 mg/kg; p.o.), both Cmax and AUC0?last increased in a slightly higher than dose-proportional manner, while t1/2 remained unchanged. Bioavailability (F) of 48 ± 5.4% and 69 ± 8.2%, respectively, leading to EPZ031686 unbound blood concentration remaining above the SMYD3 ICW IC50 value for more than 12 h after a 50 mg/kg p.o.

參考文獻(xiàn)：

1. Mitchell LH et al. Novel Oxindole Sulfonamides and Sulfamides: EPZ031686, the First Orally Bioavailable Small Molecule SMYD3 Inhibitor. ACS Med Chem Lett. 2015 Aug 27;7(2):134-8.

溶解性：

soluble in DMSO

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	1.692 ml	8.459 ml	16.918 ml
5 mM	0.338 ml	1.692 ml	3.384 ml
10 mM	0.169 ml	0.846 ml	1.692 ml
50 mM	0.034 ml	0.169 ml	0.338 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻(xiàn)

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