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LY2365109 (hydrochloride)

99.3%

N-[2-[4-(1,3-Benzodioxol-5-yl)-2-(1,1-dimethylethyl)phenoxy]ethyl]-N-methylglycine hydrochloride

質檢下載產品說明書核磁下載

品牌：源葉(MedMol)

產品編號：S83984 一鍵復制產品信息

CAS號：1779796-27-8

分子式：C₂₂H₂₈ClNO₅

分子量：421.9144

別名：LY2365109; LY 2365109; LY-2365109

貨號	規格	價格	上海	北京	武漢	南京
S83984-5mg	99.3%	￥600.00 S83984-5mg ￥600.00 現貨	6 6	-	-	-
S83984-10mg	99.3%	￥1000.00 S83984-10mg ￥1000.00 現貨	7 7	-	-	-
S83984-50mg	99.3%	￥3000.00 S83984-50mg ￥3000.00 現貨	2 2	-	-	-
S83984-100mg	≥98%	￥5000.00 S83984-100mg ￥5000.00 2-3天	0 貨期：2-3天	-	-	-

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產品介紹參考文獻質檢證書(COA) 摩爾濃度計算器相關產品

產品介紹

LY2365109 hydrochloride is a potent and selective GlyT1 inhibitor, with an IC50 of 15.8 nM for glycine uptake in cells over-expressing hGlyT1a

產品描述：

LY2365109 hydrochloride is a potent and selective GlyT1 inhibitor, with an IC50 of 15.8 nM for glycine uptake in cells over-expressing hGlyT1a

靶點：

hGlyT1:15.8 nM nM (IC50);GlyT

體內研究：

LY2365109 hydrochloride (0.3-30 mg/kg; p.o.) produces dose-dependent elevations in CSF levels of glycine.
LY2365109 hydrochloride increases seizure thresholds in mice. Animal Model: Male Sprague-Dawley rats (250-300 g) Dosage: 0.3 mg/kg, 1 mg/kg, 5 mg/kg, 10 mg/kg, 30 mg/kg Administration: Oral administration Result: Produced dose-dependent elevations in CSF levels of glycine measured 1 h after dosing.

參考文獻：

1. Perry KW et al. Neurochemical and behavioral profiling of the selective GlyT1 inhibitors ALX5407 and LY2365109 indicate a preferential action in caudal vs. cortical brain areas. Neuropharmacology. 2008 Oct;55(5):743-54.
2. Shen HY et al. Glycine transporter 1 is a target for the treatment of epilepsy. Neuropharmacology. 2015 Dec;99:554-65.

溶解性：

Soluble in DMSO

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.37 ml	11.851 ml	23.701 ml
5 mM	0.474 ml	2.37 ml	4.74 ml
10 mM	0.237 ml	1.185 ml	2.37 ml
50 mM	0.047 ml	0.237 ml	0.474 ml