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6-FORMYLINDOLO [3,2-B] CARBAZOLE

    95%

6-FORMYLINDOLO [3,2-B] CARBAZOLE

源葉(MedMol)
S83917
172922-91-7
C19H12N2O
284.31
6-甲酰基吲哚并[3,2-B]咔唑;吲哚并[3,2-B]咔唑-6-甲醛;6-FORMYLINDOLO [3,2-B] CARBAZOLE;Indolo[3,2-b]carbazole-6-carbaldehyde;5,11-dihydroindolo[3,2-b]carbazole-6-carbaldehyde;FICZ
品牌 貨號 產品規格 價格(RMB) 庫存(上海) 北京 武漢 南京 購買數量
源葉(MedMol) S83917-1mg 95% ¥550.00元 1 - - -
源葉(MedMol) S83917-5mg 95% ¥1400.00元 5 - - -
源葉(MedMol) S83917-10mg 95% ¥2100.00元 3 - - -
源葉(MedMol) S83917-25mg 95% ¥3500.00元 5 - - -
源葉(MedMol) S83917-50mg 95% ¥6500.00元 5 - - -
產品介紹 參考文獻(1篇) 質檢證書(COA) 摩爾濃度計算器 相關產品

產品介紹

FICZ (6-Formylindolo[3,2-b]carbazole) 是一種 aryl hydrocarbon receptor (AhR) 的有效激動劑,可被AHR調節的細胞色素P4501酶有效地代謝
產品描述: FICZ (6-Formylindolo[3,2-b]carbazole) 是一種 aryl hydrocarbon receptor (AhR) 的有效激動劑,可被AHR調節的細胞色素P4501酶有效地代謝
靶點: AhR;ArylHydrocarbonReceptor
體內研究: FICZ improves the atopic dermatitis-like skin inflammation, clinical scores, and transepidermal water loss in NC/Nga mice compared with those of control mice. On histology, FICZ significantly reduces the epidermal and dermal thickness as well as the number of mast cells. Topical FICZ also significantly reduces the gene expression of Il22.
細胞實驗: Cell lines: Human immortalized HaCaT cells, normal human epidermal keratinocytes (NHEKs) Concentrations: 1 nM, 10 nM, 100 nM Incubation Time: 1 h, 3 h, 5 h Method: HaCaTcells or NHEKs (1×104 cells/well) are platedon an 8-well μ-slide for 48 h, and treated with or without FICZ for 3 or 1 h, respectively. Then, the cells are washed with phosphate-buffered saline (PBS), fixed with acetone for 10 min, and blocked with 5% (w/v) bovine serum albumin in PBS for 30 min. The cells are then incubated with primary rabbit anti-AHR antibody (1:100) overnight at 4 ℃. Specific binding is detected using a horseradish peroxidase-conjugated goat anti-rabbit anti-body followed by tyramide labeling with green-fluorescent Alexa Fluor 488 for 1 h at room temperature in accordance with the manufacturer's instructions.
動物實驗: Animal Models: 9–10 week-old female NC/Nga mice Dosages: 100 mg/affected area Administration: Topical
參考文獻: 1. Emma Wincent, et al. Biochem Pharmacol. 2016 Jun 15;110-111:117-29. 2. Mari Kiyomatsu-Oda, et al. J Dermatol Sci. 2018 Jun;90(3):284-294.
溶解性: Soluble  in  DMSO
保存條件: 2-8℃
配置溶液濃度參考:
1mg 5mg 10mg
1 mM 3.517 ml 17.586 ml 35.173 ml
5 mM 0.703 ml 3.517 ml 7.035 ml
10 mM 0.352 ml 1.759 ml 3.517 ml
50 mM 0.07 ml 0.352 ml 0.703 ml
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質檢證書(COA)

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批號:JS298415 貨號:S20001-25g
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摩爾濃度計算器

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