貨號	規格	價格	上海	北京	武漢	南京
S83871-5mg	≥98%	￥990.00 S83871-5mg ￥990.00 2-3天	0 貨期：2-3天	-	-	-
S83871-10mg	≥98%	￥1380.00 S83871-10mg ￥1380.00 2-3天	0 貨期：2-3天	-	-	-
S83871-50mg	≥98%	￥4900.00 S83871-50mg ￥4900.00 2-3天	0 貨期：2-3天	-	-	-

產品介紹

Ro 25-6981 is a potent, selective and activity-dependent NR2B subunit specific NMDA receptor antagonist. Ro 25-6981 shows anticonvulsant and anti-parkinsonian activity. Ro 25-6981 has the potential for the research of parkinson's disease (PD)

產品描述：

靶點：

NMDA Receptor;NMDAR

體內研究：

Ro 25-6981 (0.39-12.5 mg/kg; i.p.) induces contraversive rotations in 6-hydroxydopamine (6-OHDA)-lesioned rats without stimulating locomotion in normal rats. Ro 25-6981 (1,3 mg/kg; i.p.) exhibits age- and activation-dependent anticonvulsant action at early postnatal development in rats. Ro 25-6981 (800 μg; intrathecal injection) shows significant analgesic effects on incision pain in rats and effectively attenuated postoperative hyperalgesia

參考文獻：

1. L?schmann PA, et al. Antiparkinsonian activity of Ro 25-6981, a NR2B subunit specific NMDA receptor antagonist, in animal models of Parkinson's disease. Exp Neurol. 2004 May;187(1):86-93. 2. Szczurowska E,et al. Different action of a specific NR2B/NMDA antagonist Ro 25-6981 on cortical evoked potentials and epileptic afterdischarges in immature rats. Brain Res Bull. 2015 Feb;111:1-8. 3. Jiang M, et al. Antinociception and prevention of hyperalgesia by intrathecal administration of Ro 25-6981, a highly selective antagonist of the 2B subunit of N-methyl-D-aspartate receptor. Pharmacol Biochem Behav. 2013 Nov;112:56-63.

溶解性：

Soluble in DMSO

保存條件：

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.195 ml	10.976 ml	21.952 ml
5 mM	0.439 ml	2.195 ml	4.39 ml
10 mM	0.22 ml	1.098 ml	2.195 ml
50 mM	0.044 ml	0.22 ml	0.439 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

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Ro 25-6981

(AR,BS)-ALPHA-(4-HYDROXYPHENYL)-BETA-METHYL-4-(PHENYLMETHYL)-1-PIPERIDINEPROPANOL MALEATE