貨號	規(guī)格	價(jià)格	上海	北京	武漢	南京
S83773-1mg	99.9%	￥212.00 S83773-1mg ￥212.00 現(xiàn)貨	9 9	-	-	-
S83773-2mg	99.9%	￥365.00 S83773-2mg ￥365.00 現(xiàn)貨	8 8	-	-	-
S83773-5mg	99.9%	￥671.00 S83773-5mg ￥671.00 現(xiàn)貨	8 8	-	-	-
S83773-10mg	99.9%	￥1062.00 S83773-10mg ￥1062.00 現(xiàn)貨	6 6	-	-	-
S83773-25mg	99.9%	￥1530.00 S83773-25mg ￥1530.00 現(xiàn)貨	5 5	-	-	-
S83773-50mg	99.9%	￥2450.00 S83773-50mg ￥2450.00 現(xiàn)貨	4 4	-	-	-
S83773-100mg	99.9%	￥4200.00 S83773-100mg ￥4200.00 現(xiàn)貨	5 5	-	-	-

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產(chǎn)品介紹

YM-90709 is a novel IL-5 inhibitor which selectively blocks the binding of IL-5 to the IL-5 receptor (IL-5R).YM-90709 potently inhibits the binding of [125I]-IL-5 to IL-5R on human peripheral eosinophils and eosinophilic HL-60 clone 15 cells with IC50 values of 1.0 and 0.57 μM

產(chǎn)品描述：

靶點(diǎn)：

IL-5;ILReceptor;?Interleukin

體內(nèi)研究：

YM-90709 (0.01-10 mg/kg; intravenous injection, 72 hours, Inbred female Brown-Norway (BN) rats) results in the inhibition of antigen-induced infiltration of eosinophils and lymphocytes, but not neutrophils or monocytes, into the bronchoalveolar lavage fluid (BALF) of Brown-Norway (BN) rats

參考文獻(xiàn)：

1. Morokata T, et al. Characterization of YM-90709 as a novel antagonist which inhibits the binding of interleukin-5 to interleukin-5 receptor. Int Immunopharmacol. 2002 Nov;2(12):1693-702. 2. Morokata T, et al. Effect of a novel interleukin-5 receptor antagonist, YM-90709, on antigen-induced eosinophil infiltration into the airway of BDF1 mice. Immunol Lett. 2005 Apr 15;98(1):161-5.

溶解性：

DMSO : 62.5 mg/mL (173.89 mM; Need ultrasonic)

保存條件：

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.782 ml	13.911 ml	27.823 ml
5 mM	0.556 ml	2.782 ml	5.565 ml
10 mM	0.278 ml	1.391 ml	2.782 ml
50 mM	0.056 ml	0.278 ml	0.556 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻(xiàn)

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YM-90709

5,6-DIHYDRO-2,3-DIMETHOXY-6,6-DIMETHYLBENZ[7,8]INDOLIZINO[2,3-B]QUINOXALINE