貨號	規(guī)格	價格	上海	北京	武漢	南京
S83611-5mg	99.6%	￥340.00 S83611-5mg ￥340.00 現(xiàn)貨	19810 >10	-	-	-
S83611-10mg	99.6%	￥552.00 S83611-10mg ￥552.00 現(xiàn)貨	9910 >10	-	-	-
S83611-25mg	99.6%	￥850.00 S83611-25mg ￥850.00 現(xiàn)貨	3970 >10	-	-	-
S83611-50mg	99.6%	￥1275.00 S83611-50mg ￥1275.00 現(xiàn)貨	1992 >10	-	-	-
S83611-250mg	≥98%	￥2975.00 S83611-250mg ￥2975.00 現(xiàn)貨	396 >10	-	-	-

產(chǎn)品介紹

Omberacetam is a synthetic dipeptide that has been shown to produce positive nootropic and cognitive effects in animal models by a mechanism similar to other related racetam compounds.

產(chǎn)品描述：

Omberacetam is a synthetic dipeptide that has been shown to produce positive nootropic and cognitive effects in animal models by a mechanism similar to other related racetam compounds.

靶點(diǎn)：

iGluR;Others;?iGluR

體內(nèi)研究：

Noopept eliminated the manifestations of learned helplessness after long-term (21-day) treatment by increasing the percent of trained animals

細(xì)胞實(shí)驗(yàn)：

PC12 cells were cultured routinely at 37°C in DMEM medium, supplemented with 10% fetal bovine serum (FBS), 5% horse serum, 2 mM L-glutamine, 50 μg/ml gentamicin. To induce PC12 differentiation, NGF (50 ng/ml) was added to the DMEM containing 1% FBS, followed by a 5-day incubation. Differentiated PC12 (dPC12) cells were pretreated with noopept at concentration of 10 μM for 72 h, then cells were rinsed with the medium and exposed to amyloid-β-peptide (Аβ25–35;5 μM) for 24 h. Untreated cells were used as control

動物實(shí)驗(yàn)：

Experiments were carried out on adult outbred albino male rats (n=376; 250-300 g) kept under vivarium conditions with 12-h light period with free access to water and standard food. The operant training was performed in a modified setup for active avoidance conditioning under conditions of uncertain environment.The animals were intraperitoneally injected (1 ml/kg) with noopept (0.1, 0.5, and 1.0 mg/kg) and piracetam (100, 300, and 500 mg/kg; reference drug), afobazol (1, 5, and 10 mg/kg), and buspiron (0.5, 1.0, and 5.0 mg/kg; reference drug) and diazepam (0.05, 0.1, and 0.5 mg/kg; reference drug). Control rats were injected with the same volume of saline. Stability of active avoidance behavior was tested after 48 h and 7 days. The animals with learned helplessness neurosis were injected with noopept and afobazol for 21 days, after which stability of the active avoidance behavior was repeatedly tested

參考文獻(xiàn)：

1.Ostrovskaya R U , Vakhitova Y V , Uliyana Sh Kuzmina…. Neuroprotective effect of novel cognitive enhancer noopept on AD-related cellular model involves the attenuation of apoptosis and tau hyperphosphorylation[J]. Journal of Biomedical Science, 2014, 21(1). 2.Uyanaev A A , Fisenko V P . Studies of long-term noopept and afobazol treatment in rats with learned helplessness neurosis[J]. Bulletin of Experimental Biology & Medicine, 2006, 142(2):202-204.

溶解性：

DMSO:100 mg/mL (314.10 mM)

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	3.141 ml	15.705 ml	31.41 ml
5 mM	0.628 ml	3.141 ml	6.282 ml
10 mM	0.314 ml	1.57 ml	3.141 ml
50 mM	0.063 ml	0.314 ml	0.628 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻(xiàn)

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