貨號	規格	價格	上海	北京	武漢	南京
S83605-2mg	99.4%	￥340.00 S83605-2mg ￥340.00 現貨	5 5	-	-	-
S83605-5mg	99.4%	￥510.00 S83605-5mg ￥510.00 現貨	6 6	-	-	-
S83605-10mg	99.4%	￥935.00 S83605-10mg ￥935.00 現貨	5 5	-	-	-
S83605-25mg	≥96%	￥2040.00 S83605-25mg ￥2040.00 2-3天	0 貨期：2-3天	-	-	-
S83605-50mg	≥96%	￥3315.00 S83605-50mg ￥3315.00 2-3天	0 貨期：2-3天	-	-	-
S83605-100mg	≥96%	￥6120.00 S83605-100mg ￥6120.00 2-3天	0 貨期：2-3天	-	-	-

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產品介紹

Rostafuroxin (PST 2238), a digitoxigenin derivative, is an orally active and potent Na+,K+-ATPase (ATP1A1) antognist. Rostafuroxin binds specifically to the ATP1A1 extracellular domain and blocks respiratory syncytial virus (RSV)-triggered EGFR Tyr845 phosphorylation. Rostafuroxin has antihypertensive and anti-RSV activity

產品描述：

靶點：

Na+/K+ ATPase;RSV;ATPase;?RSV

體內研究：

Rostafuroxin (PST 2238; 1 mg/kg/day; gavage; for 3 weeks) decreases SBP and improves acetylcholine-induced relaxation

參考文獻：

1. Quadri L, et al. 17 beta-(3-furyl)-5 beta-androstane-3 beta, 14 beta, 17 alpha-triol (PST 2238). A very potent antihypertensive agent with a novel mechanism of action. J Med Chem. 1997 May 23;40(11):1561-4. 2. Ferrari P, et al. PST 2238: A new antihypertensive compound that modulates Na,K-ATPase in genetic hypertension. J Pharmacol Exp Ther. 1999 Mar;288(3):1074-83. 3. Matthias Lingemann, et al. The alpha-1 subunit of the Na+,K+-ATPase (ATP1A1) is required for macropinocytic entry of respiratory syncytial virus (RSV) in human respiratory epithelial cells. PLoS Pathog. 2019 Aug 5;15(8):e1007963. 4. Camilla F Wenceslau, et al. Rostafuroxin ameliorates endothelial dysfunction and oxidative stress in resistance arteries from deoxycorticosterone acetate-salt hypertensive rats: the role of Na+,K+-ATPase/cSRC pathway. J Hypertens. 20

溶解性：

DMSO : ≥ 50 mg/mL (133.51 mM)

保存條件：

2-8℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.67 ml	13.351 ml	26.702 ml
5 mM	0.534 ml	2.67 ml	5.34 ml
10 mM	0.267 ml	1.335 ml	2.67 ml
50 mM	0.053 ml	0.267 ml	0.534 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

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ROSTAFUROXIN

(3β,5β,14β)-21,23-Epoxy-24-Norchola-20,22-diene-3,14,17-triol