| 產(chǎn)品描述： | 4-IBP是選擇性σ1 receptor激動(dòng)劑，對(duì)σ1受體具有高親和力，Ki值為1.7 nM，而對(duì)σ2受體的親和力較弱，Ki值為25.2 nM |
| 靶點(diǎn)： |
σ1 receptor:1.7 nM(Ki); σ2 receptor:25.2 nM(Ki);Sigmareceptor |
| 體外研究： |
4-IBP decreases the migration levels of various types of cancer cells, including C32 melanoma, U373-MG glioblastoma, A549 NSCLC, and PC3 prostate cancer cells. 4-IBP modifies the sensitivity of U373-MG cells in vitro to proapoptotic lomustin and proautophagic temozolomide, and markedly decreases the expression of two proteins involved in drug resistance: glucosylceramide synthase and Rho guanine nucleotide dissociation inhibitor |
| 體內(nèi)研究： |
In vivo, 4-IBP increases the antitumor effects of temozolomide and irinotecan in immunodeficient mice that are orthotopically grafted with invasive cancer cells |
| 參考文獻(xiàn)： |
1. Mégalizzi V, et al. 4-IBP, a sigma1 receptor agonist, decreases the migration of human cancer cells, including glioblastoma cells, in vitro and sensitizes them in vitro and in vivo to cytotoxic insults of proapoptotic and proautophagic drugs. Neoplasia. 2007, 9(5):358-69. |
| 溶解性： |
Soluble in DMSO、Ethanol |
| 保存條件： |
-20℃ |
| 配置溶液濃度參考： |
|
1mg |
5mg |
10mg |
| 1 mM |
2.379 ml |
11.897 ml |
23.793 ml |
| 5 mM |
0.476 ml |
2.379 ml |
4.759 ml |
| 10 mM |
0.238 ml |
1.19 ml |
2.379 ml |
| 50 mM |
0.048 ml |
0.238 ml |
0.476 ml |
|
| 注意： |
部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。 |
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