貨號	規格	價格	上海	北京	武漢	南京
S83439-10mg	98.7%	￥190.00 S83439-10mg ￥190.00 現貨	8 8	-	-	-
S83439-50mg	98.7%	￥440.00 S83439-50mg ￥440.00 現貨	8 8	-	-	-
S83439-100mg	98.7%	￥700.00 S83439-100mg ￥700.00 現貨	5 5	-	-	-

產品介紹

Delavirdine (U 90152) mesylate is a potent, highly specific and orally active non-nucleoside reverse transcriptase inhibitor (NNRTI). Delavirdine mesylate selectively inhibits HIV-1 reverse transcriptase (RT) (IC50=0.26 μM) over DNA polymerase α (IC50=440 μM) and polymerase δ (IC50>550 μM). Delavirdine mesylate is an inhibitor of HIV-1 replication and can can be used for the study of AIDs

產品描述：

靶點：

IC50: 0.26 μM (HIV-1 RT); 440 μM (DNA polymerase α); >550 μM (DNA polymerase δ);HIVProtease;?ReverseTranscriptase

體內研究：

Delavirdine (U 90152) mesylate (oral gavage; 10 mg/kg, 200 mg/kg, 250 mg/kg; single dose) is absorbed and metabolized rapidly, that it constitutes a minor component in circulation, that its pharmacokinetics are nonlinear, and that its metabolism to desalkyl delavirdine is capacity limited or inhibitable in CD-1 mice (PK study)

參考文獻：

1. Dueweke TJ, et al. U-90152, a potent inhibitor of human immunodeficiency virus type 1 replication. Antimicrob Agents Chemother. 1993 May;37(5):1127-31. 2. Mayland Chang, et al. Metabolism of the HIV-1 Reverse Transcriptase Inhibitor Delavirdine In Mice. Research Article

溶解性：

DMSO : ≥ 40.3 mg/mL (72.92 mM)

保存條件：

2-8℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	1.809 ml	9.047 ml	18.094 ml
5 mM	0.362 ml	1.809 ml	3.619 ml
10 mM	0.181 ml	0.905 ml	1.809 ml
50 mM	0.036 ml	0.181 ml	0.362 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

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