貨號	規格	價格	上海	北京	武漢	南京
S83420-1mg	99.5%	￥290.00 S83420-1mg ￥290.00 現貨	10 10	-	-	-
S83420-5mg	99.5%	￥730.00 S83420-5mg ￥730.00 現貨	5 5	-	-	-
S83420-10mg	99.5%	￥1030.00 S83420-10mg ￥1030.00 現貨	5 5	-	-	-
S83420-50mg	99.5%	￥2320.00 S83420-50mg ￥2320.00 現貨	2 2	-	-	-
S83420-100mg	≥99%	￥3150.00 S83420-100mg ￥3150.00 2-3天	0 貨期：2-3天	-	-	-

產品介紹

BM212 is a potent Mycobacterial membrane protein Large 3 (MmpL3) inhibitor. BM212 has strong bactericidal activity against both M. tuberculosis and some nontuberculosis mycobacteria. BM212 exhibits antimycobacterial activity against M. tuberculosis H37Rv with an MIC of 5 μM

產品描述：

靶點：

M. tuberculosis;Antibacterial

體外研究：

BM212 (2 μg/mL and 8 μg/mL) leads to major structural changes in the cell of M. abscessus CIP104536T S and R variants and results in the complete loss of the hydrophobic nanodomains observed on S cells but no significantly affect on R cells at dose of 2 μg/mL. BM212 (0.5-10 μg/mL, 7 days) inhibits the activity of Mycobacterium avium in U937 cells in a dose-dependent manner with a MIC of 0.5 μg/mL and 100% inhibition starting at a concentration of 1 μg/mL

參考文獻：

1. Deidda D et al. Bactericidal activities of the pyrrole derivative BM212 against multidrug-resistant and intramacrophagic Mycobacterium tuberculosis strains. Antimicrob Agents Chemother. 1998 Nov;42(11):3035-7. 2. Poce G et al. Improved BM212 MmpL3 inhibitor analogue shows efficacy in acute murine model of tuberculosis infection. PLoS One. 2013;8(2) 3. Albertus Viljoen, et al. Fast chemical force microscopy demonstrates that glycopeptidolipids define nanodomains of varying hydrophobicity on mycobacteria. Nanoscale Horiz. 2020 Jun 1;5(6):944-953. 4. Delia Deidda, et al. Bactericidal activities of the pyrrole derivative BM212 against multidrug-resistant and intramacrophagic Mycobacterium tuberculosis strains. Antimicrob Agents Chemother. 1998 Nov;42(11):3035-7.

溶解性：

Soluble in DMSO、Ethanol

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.413 ml	12.066 ml	24.133 ml
5 mM	0.483 ml	2.413 ml	4.827 ml
10 mM	0.241 ml	1.207 ml	2.413 ml
50 mM	0.048 ml	0.241 ml	0.483 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

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