貨號	規格	價格	上海	北京	武漢	南京
S83379-1mg	99.2%	￥990.00 S83379-1mg ￥990.00 現貨	10 10	-	-	-
S83379-5mg	99.2%	￥1980.00 S83379-5mg ￥1980.00 現貨	6 6	-	-	-
S83379-10mg	99.2%	￥3200.00 S83379-10mg ￥3200.00 現貨	6 6	-	-	-
S83379-25mg	99.2%	￥5100.00 S83379-25mg ￥5100.00 現貨	6 6	-	-	-

產品介紹

Senexin B is a potent and selective inhibitor of CDK8/19(CDK8 and CDK19 with Kds of 140 nM and 80 nM).

產品描述：

Senexin B is a potent and selective inhibitor of CDK8/19(CDK8 and CDK19 with Kds of 140 nM and 80 nM).

靶點：

CDK

體外研究：

Senexin B inhibits CDK8/19 in low nanomolar range

體內研究：

In a spleen-to-liver colon cancer metastasis model of syngeneic mouse CT26 tumors, Senexin B treatment of mice had the same effect as CDK8 knockdown in tumor cells: suppression of metastatic growth in the liver without a significant effect on primary tumor growth in the spleen

參考文獻：

1. Chen M , Li J , Liang J , et al. Systemic Toxicity Reported for CDK8/19 Inhibitors CCT251921 and MSC2530818 Is Not Due to Target Inhibition[J]. 2019. 2. Porter D, et al. Abstract PR08: Targeting tumor microenvironment with selective small-molecule inhibitors of CDK8/19. Abstracts: AACR Special Conference on Cellular Heterogeneity in the Tumor Microenvironment; 2014 Feb 26-Mar 1; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2015;75(1 Suppl):Abstract nr PR08. doi:10.1158/1538-7445.CHTME14-PR08

溶解性：

Soluble in DMSO

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.22 ml	11.098 ml	22.196 ml
5 mM	0.444 ml	2.22 ml	4.439 ml
10 mM	0.222 ml	1.11 ml	2.22 ml
50 mM	0.044 ml	0.222 ml	0.444 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

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