貨號	規格	價格	上海	北京	武漢	南京
S83343-5mg	99.1%	￥200.00 S83343-5mg ￥200.00 現貨	8 8	-	-	-
S83343-10mg	99.1%	￥330.00 S83343-10mg ￥330.00 現貨	6 6	-	-	-
S83343-50mg	99.1%	￥920.00 S83343-50mg ￥920.00 現貨	3 3	-	-	-

產品介紹

AM-2394 is a structurally distinct glucokinase activator (GKA). AM-2394 activates glucokinase (GK) with an EC50 of 60 nM

產品描述：

AM-2394 is a structurally distinct glucokinase activator (GKA). AM-2394 activates glucokinase (GK) with an EC50 of 60 nM

靶點：

EC50: 60 nM (glucokinase);Glucokinase

體內研究：

AM-2394, a structurally distinct glucokinase activator that displays a robust reduction in plasma glucose during an oral glucose tolerance test (OGTT) in ob/ob mice at a dose of 3 mg/kg. AM-2394 increases the affinity of glucokinase (GK) for glucose by approximately 10-fold, exhibits moderate clearance and good oral bioavailability in multiple animal models, and lowers glucose excursion following an oral glucose tolerance test in an ob/ob mouse model of diabetes. AM-2394 exhibits good-to-moderate cross species plasma clearance, volume of distribution, and oral bioavailability, allowing for further evaluation in animal models

參考文獻：

1. Dransfield PJ, et al. Novel Series of Potent Glucokinase Activators Leading to the Discovery of AM-2394. ACS Med Chem Lett. 2016 May 23;7(7):714-8.

溶解性：

Soluble in DMSO

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.361 ml	11.807 ml	23.615 ml
5 mM	0.472 ml	2.361 ml	4.723 ml
10 mM	0.236 ml	1.181 ml	2.361 ml
50 mM	0.047 ml	0.236 ml	0.472 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

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