貨號	規格	價格	上海	北京	武漢	南京
S83316-2mg	99.9%	￥190.40 S83316-2mg ￥190.40 現貨	5 5	-	-	-
S83316-5mg	99.9%	￥290.00 S83316-5mg ￥290.00 現貨	3 3	-	-	-
S83316-10mg	99.9%	￥455.00 S83316-10mg ￥455.00 現貨	6 6	-	-	-
S83316-25mg	99.9%	￥730.00 S83316-25mg ￥730.00 現貨	6 6	-	-	-
S83316-50mg	≥98%	￥1250.00 S83316-50mg ￥1250.00 2-3天	0 貨期：2-3天	-	-	-
S83316-100mg	≥98%	￥2000.00 S83316-100mg ￥2000.00 2-3天	0 貨期：2-3天	-	-	-

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產品介紹

3-AP (PAN-811) is a potent inhibitor of the M2 subunit of ribonucleotide reductase (RR), and is a potent radiosensitizer.

產品描述：

3-AP (PAN-811) is a potent inhibitor of the M2 subunit of ribonucleotide reductase (RR), and is a potent radiosensitizer.

靶點：

Ribonucleotide reductase (RR);DNA/RNASynthesis

體內研究：

3-AP (Triapine) causes a significant increase (1.7-fold) in splenic weight when expressed as a percentage of total body weight (1.02±0.06%; n=25) compared with control mice (0.6±0.03%; n=27). In the long-term group, a significant increase in heart weight is observed after Dp44mT (0.4 mg/kg per day) (0.8±0.06%; n=4) compared with control mice (0.5±0.01%; n=6). A significant decrease in the expression of Ndrg1, TfR1, and VEGF1 in the liver is noted for Dp44mT- and 3-AP (12 mg/kg per day)-treated animals. The decreased expression could be related to the increased liver Fe in both Dp44mT- and 3-AP-treated mice

參考文獻：

1. Martin LK, et al. A dose escalation and pharmacodynamic study of Triapine and radiation in patients with locally advanced pancreas cancer. Int J Radiat Oncol Biol Phys. 2012 Nov 15;84(4):e475-81. 2. Yalowich JC, et al. The anticancer thiosemicarbazones Dp44mT and Triapine lack inhibitory effects as catalytic inhibitors or poisons of DNA topoisomerase IIα. Biochem Pharmacol. 2012 Jul 1;84(1):52-8. 3. Whitnall M, et al. A class of iron chelators with a wide spectrum of potent antitumor activity that overcomes resistance to chemotherapeutics. Proc Natl Acad Sci U S A. 2006 Oct 3;103(40):14901-6.

溶解性：

DMSO : ≥ 47 mg/mL (240.73 mM)

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	5.122 ml	25.609 ml	51.218 ml
5 mM	1.024 ml	5.122 ml	10.244 ml
10 mM	0.512 ml	2.561 ml	5.122 ml
50 mM	0.102 ml	0.512 ml	1.024 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

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3-AP ( PAN-811)

3-aminopyridine-2-carboxaldehyde thiosemicarbazone