貨號(hào)	規(guī)格	價(jià)格	上海	北京	武漢	南京
S83308-1mg	99.1%	￥160.00 S83308-1mg ￥160.00 現(xiàn)貨	9 9	-	-	-
S83308-5mg	99.1%	￥240.00 S83308-5mg ￥240.00 現(xiàn)貨	7 7	-	-	-
S83308-10mg	99.1%	￥350.00 S83308-10mg ￥350.00 現(xiàn)貨	9 9	-	-	-
S83308-25mg	99.1%	￥640.00 S83308-25mg ￥640.00 現(xiàn)貨	6 6	-	-	-
S83308-50mg	99.1%	￥1030.00 S83308-50mg ￥1030.00 現(xiàn)貨	8 8	-	-	-
S83308-100mg	99.1%	￥2010.00 S83308-100mg ￥2010.00 現(xiàn)貨	6 6	-	-	-

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產(chǎn)品介紹

Firsocostat (GS-0976, NDI-010976, ND-630)是acetyl CoA carboxylase (ACC)的一種可逆抑制劑，對hACC1和hACC2的IC50分別為2.1 nM，6.1 nM

產(chǎn)品描述：

Firsocostat (GS-0976, NDI-010976, ND-630)是acetyl CoA carboxylase (ACC)的一種可逆抑制劑，對hACC1和hACC2的IC50分別為2.1 nM，6.1 nM

靶點(diǎn)：

hACC1(Cell-free assay):2.1 nM; hACC2(Cell-free assay):6.1 nM;Acetyl-CoACarboxylase

體外研究：

When ND-630 and [14C]acetate were administered to Hep-G2 cells for 4 h, ND-630 inhibited FASyn with EC50 values of 66 nM in cells cultured in medium containing. When ND-630 and[14C]palmitate were administered to C2C12 cells for 6 h, ND-630 increased both the release of [14C]O2?and the production of[14C]acid-soluble material

體內(nèi)研究：

When administered chronically to rats with diet-induced obesity, ND-630 reduces hepatic steatosis, improves insulin sensitivity, reduces weight gain without affecting food intake, and favorably affects dyslipidemia

細(xì)胞實(shí)驗(yàn)：

Cell lines: HepG2 cells Concentrations: 2.1 nM (ACC1); 6.1 nM (ACC2) Incubation Time: 1 h Method: Cells were treated with varying concentrations of ND-630.

動(dòng)物實(shí)驗(yàn)：

Animal Models: Male Sprague–Dawley rats Dosages: 10 mg/kg Administration: o.g.

參考文獻(xiàn)：

1. Harriman G,et al. Acetyl-CoA carboxylase inhibition by ND-630 reduces hepatic steatosis, improves insulin sensitivity, and modulates dyslipidemia in rats. Proc Natl Acad Sci U S A.2016 29;113(13):E1796-805.

溶解性：

Soluble in DMSO、Ethanol

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	1.756 ml	8.778 ml	17.555 ml
5 mM	0.351 ml	1.756 ml	3.511 ml
10 mM	0.176 ml	0.878 ml	1.756 ml
50 mM	0.035 ml	0.176 ml	0.351 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻(xiàn)

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