貨號	規(guī)格	價格	上海	北京	武漢	南京	購買數(shù)量
S83284-5mg	≥98%	￥2400.00 S83284-5mg ￥2400.00 2-3天	0 貨期：2-3天	-	-	-
S83284-10mg	≥98%	￥3200.00 S83284-10mg ￥3200.00 2-3天	0 貨期：2-3天	-	-	-

產(chǎn)品介紹

CAL-130 is a PI3Kδ and PI3Kγ inhibitor with IC50s of 1.3 and 6.1 nM, respectively.

產(chǎn)品描述：

CAL-130 is a PI3Kδ and PI3Kγ inhibitor with IC50s of 1.3 and 6.1 nM, respectively.

靶點：

p110δ:1.3 nM (IC50);p110γ:6.1 nM (IC50);p110β:56 nM (IC50);p110α:115 nM (IC50);PI3K

體外研究：

CAL-130 preferentially inhibits the function of both p110γ and p110δ catalytic domains. IC50 values of CAL-130 are 1.3 and 6.1 nM for p110δ and p110γ, respectively, as compared to 115 and 56 nM for p110α and p110β. CAL-130 does not inhibit additional intracellular signaling pathways (i.e., p38 MAPK or insulin receptor tyrosine kinase) that are critical for general cell function and survival

體內(nèi)研究：

The clinical significance of interfering with the combined activities of PI3Kγ and PI3Kδ is determined by administering CAL-130 to Lck/Ptenfl/fl mice with established T cell acute lymphoblastic leukemia (T-ALL). Candidate animals for survival studies are ill appearing, have a white blood cell (WBC) count above 45,000 μL-1, evidence of blasts on peripheral smear, and a majority of circulation cells (>75%) staining double positive for Thy1.2 and Ki-67. Mice receive an oral dose (10 mg/kg) of CAL-130 every 8 hr for a period of 7 days and are then followed until moribund. Despite the limited duration of therapy, CAL-130 is highly effective in extending the median survival for treated animals to 45 days as compared 7.5 days for the control group

參考文獻：

1. Subramaniam Prem S, et al. Targeting nonclassical oncogenes for therapy in T-ALL. Cancer cell (2012), 21(4), 459-72.

溶解性：

soluble in DMSO

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.16 ml	10.801 ml	21.601 ml
5 mM	0.432 ml	2.16 ml	4.32 ml
10 mM	0.216 ml	1.08 ml	2.16 ml
50 mM	0.043 ml	0.216 ml	0.432 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻

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CAL-130 (Hydrochloride)