貨號(hào)	規(guī)格	價(jià)格	上海	北京	武漢	南京
S83262-1mg	99.0%	￥600.00 S83262-1mg ￥600.00 現(xiàn)貨	5 5	-	-	-
S83262-2mg	99.0%	￥850.00 S83262-2mg ￥850.00 現(xiàn)貨	5 5	-	-	-
S83262-5mg	99.0%	￥1100.00 S83262-5mg ￥1100.00 現(xiàn)貨	5 5	-	-	-
S83262-10mg	99.0%	￥1800.00 S83262-10mg ￥1800.00 現(xiàn)貨	6 6	-	-	-
S83262-50mg	99.0%	￥5400.00 S83262-50mg ￥5400.00 現(xiàn)貨	2 2	-	-	-
S83262-100mg	≥98%	￥9000.00 S83262-100mg ￥9000.00 2-3天	0 貨期：2-3天	-	-	-

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產(chǎn)品介紹

KIN1148, a small-molecule IRF3 agonist, is a novel influenza vaccine adjuvant found to enhance flu vaccine efficacy.

產(chǎn)品描述：

KIN1148, a small-molecule IRF3 agonist, is a novel influenza vaccine adjuvant found to enhance flu vaccine efficacy.

靶點(diǎn)：

Influenza Virus;InfluenzaVirus

體外研究：

KIN1148 induces the dose-dependent nuclear translocation of IRF3 in PH5CH8 cells and specific activation of IRF3- responsive promoters. KIN1148 also elicits greater induction of endogenous IRF3-dependent ISG54 and OASL expression by PH5CH8 cells

體內(nèi)研究：

Prime-boost immunization of mice with a suboptimal dose of a monovalent pandemic influenza split virus H1N1 A/California/07/2009 vaccine plus KIN1148 protect against a lethal challenge with mouse-adapted influenza virus (A/California/04/2009) and induce an influenza virusspecific IL-10 and Th2 response by T cells derived from lung and lung-draining lymph nodes. Primeboost immunization with vaccine plus KIN1148, but not prime immunization alone, induce antibodies capable of inhibiting influenza virus hemagglutinin and neutralizing viral infectivity. Nevertheless, a single immunization with vaccine plus KIN1148 provide increased protection over vaccine alone and reduce viral load in the lungs after challenge

參考文獻(xiàn)：

1. Probst P, et al. A small-molecule IRF3 agonist functions as an influenza vaccine adjuvant by modulating the antiviral immune response. Vaccine. 2017 Apr 4;35(15):1964-1971.

溶解性：

Soluble in DMSO

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.767 ml	13.834 ml	27.667 ml
5 mM	0.553 ml	2.767 ml	5.533 ml
10 mM	0.277 ml	1.383 ml	2.767 ml
50 mM	0.055 ml	0.277 ml	0.553 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻(xiàn)

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批號(hào)：JS298415 貨號(hào)：S20001-25g
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