貨號	規格	價格	上海	北京	武漢	南京
S83243-5mg	99.9%	￥410.00 S83243-5mg ￥410.00 現貨	6 6	-	-	-
S83243-10mg	99.9%	￥580.00 S83243-10mg ￥580.00 現貨	10 10	-	-	-
S83243-50mg	99.9%	￥1590.00 S83243-50mg ￥1590.00 現貨	7 7	-	-	-
S83243-100mg	99.9%	￥2650.00 S83243-100mg ￥2650.00 現貨	5 5	-	-	-

產品介紹

Entecavir is a guanosine nucleoside analogue used in the treatment of chronic hepatitis B virus (HBV) infection. Entecavir therapy can be associated with flares of the underlying hepatitis B during or after therapy, but has not been linked to cases of clinically apparent liver injury.

產品描述：

靶點：

HBV

體內研究：

Daily oral treatment with BMS-200475 at doses ranging from 0.02 to 0.5 mg/kg of body weight for 1 to 3 months is effective in reducing the level of woodchuck hepatitis virus (WHV) viremia in chronically infected woodchucks

細胞實驗：

BMS 200475 is prepared in phosphate-buffered saline (PBS) and diluted with appropriate medium containing 2% fetal bovine serum. HepG2 2.2.15 cells are plated at a density of 5×105 cells per well on 12-well Biocoat collagen-coated plates and are maintained in a confluent state for 2 to 3 days before being overlaid with 1 mL of medium spiked with BMS 200475. Quantification of HBV was performed on day 10

參考文獻：

1. Xie B, Sun D, Du Y, et al. A two-step lineage reprogramming strategy to generate functionally competent human hepatocytes from fibroblasts[J]. Cell research. 2019: 1. 2. Sham, H., Kempf, D., Molla, A., Marsh, K., Kumar, G., & Chen, C. et al. (1998). ABT-378, a Highly Potent Inhibitor of the Human Immunodeficiency Virus Protease. Antimicrobial Agents And Chemotherapy, 42(12), 3218-3224. doi: 10.1128/aac.42.12.3218

溶解性：

Soluble in DMSO

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	3.606 ml	18.032 ml	36.064 ml
5 mM	0.721 ml	3.606 ml	7.213 ml
10 mM	0.361 ml	1.803 ml	3.606 ml
50 mM	0.072 ml	0.361 ml	0.721 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻(2篇)

2. [IF=4.6] Yanan Liu et al."QuEChERS and UPLC-MS/MS-Based Quantification of Human Plasma of Eight Nucleoside Reverse Transcriptase Inhibitors and Platinum Anticancer Drugs for Hepatocellular Carcinoma."MOLECULES.2025 Jan;30(10):2204 1. [IF=2.4] Liu Yue et al."Effect of the Deubiquitinating Peptidase 7 (USP7) on Hepatitis B Virus (HBV) Replication and the Antiviral Efficacy of Entecavir (ETV)."MOLECULAR BIOTECHNOLOGY.2024 Dec;:1-11

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摩爾濃度計算器

質量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)

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