貨號	規格	價格	上海	北京	武漢	南京
S83207-1mg	≥98%	￥290.00 S83207-1mg ￥290.00 2-3天	0 貨期：2-3天	-	-	-
S83207-2mg	≥98%	￥530.00 S83207-2mg ￥530.00 2-3天	0 貨期：2-3天	-	-	-
S83207-5mg	≥98%	￥950.00 S83207-5mg ￥950.00 2-3天	0 貨期：2-3天	-	-	-
S83207-10mg	≥98%	￥1250.00 S83207-10mg ￥1250.00 2-3天	0 貨期：2-3天	-	-	-
S83207-25mg	≥98%	￥2800.00 S83207-25mg ￥2800.00 2-3天	0 貨期：2-3天	-	-	-
S83207-50mg	≥98%	￥4800.00 S83207-50mg ￥4800.00 2-3天	0 貨期：2-3天	-	-	-

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產品介紹

TG6-10-1 is an EP2 antagonist, shows low-nanomolar antagonist activity against only EP2, >300-fold selectivity over human EP3, EP4, and IP receptors, 100-fold selectivity over EP1 receptors

產品描述：

TG6-10-1 is an EP2 antagonist, shows low-nanomolar antagonist activity against only EP2, >300-fold selectivity over human EP3, EP4, and IP receptors, 100-fold selectivity over EP1 receptors

靶點：

EP2;5-HTReceptor;?ProstaglandinReceptor

體外研究：

TG6-10-1 robustly blocks prostaglandin E2 (PGE2) (10 μM)-induced cAMP accumulation in a concentration-dependent manner in SH-SY5Y cells

體內研究：

TG6-10-1 (5 mg/kg; i.p.; 4-30 hours) improves survival, accelerates recovery of lost weight, and improves functional recovery following status epilepticus (SE). Animal Model: C57BL/6 mice (pilocarpine-induced SE) Dosage: 5 mg/kg Administration: Intraperitoneal injection; 4, 21, 30 hours Result: A significant increase in survival and accelerating the recovery of lost weight in post-SE mice.

參考文獻：

1. Jiang J, et al. Inhibition of the prostaglandin receptor EP2 following status epilepticus reduces delayed mortality and brain inflammation. Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):3591-3596. 2. Kang X, et al. Cyclooxygenase-2 contributes to oxidopamine-mediated neuronal inflammation and injury via the prostaglandin E2 receptor EP2 subtype. Sci Rep. 2017 Aug 25;7(1):9459.

溶解性：

soluble in DMSO

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.23 ml	11.15 ml	22.3 ml
5 mM	0.446 ml	2.23 ml	4.46 ml
10 mM	0.223 ml	1.115 ml	2.23 ml
50 mM	0.045 ml	0.223 ml	0.446 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

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