貨號(hào)	規(guī)格	價(jià)格	上海	北京	武漢	南京
S83175-1mg	99.6%	￥280.00 S83175-1mg ￥280.00 現(xiàn)貨	5 5	-	-	-
S83175-5mg	99.6%	￥650.00 S83175-5mg ￥650.00 現(xiàn)貨	6 6	-	-	-
S83175-10mg	99.6%	￥1147.00 S83175-10mg ￥1147.00 現(xiàn)貨	6 6	-	-	-
S83175-50mg	99.6%	￥2700.00 S83175-50mg ￥2700.00 現(xiàn)貨	3 3	-	-	-
S83175-100mg	≥95%	￥4100.00 S83175-100mg ￥4100.00 2-3天	0 貨期：2-3天	-	-	-

產(chǎn)品介紹

T807 a novel tau positron emission tomography (PET) tracer.

產(chǎn)品描述：

T807 a novel tau positron emission tomography (PET) tracer.

靶點(diǎn)：

Tau Protein;MicrotubuleAssociated

體外研究：

Aggregated tau protein is a major neuropathological substrate central to the pathophysiology of neurodegenerative diseases such as Alzheimer's disease (AD). In vitro autoradiography results show that [18F]T807 exhibits strong binding to PHF-tau positive human brain sections (Kd=14.6 nM). A comparison of autoradiography and double immunohistochemical staining of PHF-tau and Ab on adjacent sections demonstrates that [18F]T807 binding colocalizes with immunoreactive PHF-tau pathology, but does not highlight Ab plaques. [18F]T807 strongly binds to tau lesions primarily made of paired helical filaments in Alzheimer’s brains e.g. intra and extraneuronal tangles and dystrophic neurites. [18F]T807 off-target binding to neuromelanin- and melanin-containing cells and, to a lesser extent, to brain hemorrhagic lesions is identified

體內(nèi)研究：

[18F]T807 is able to cross the blood–brain barrier and ished out quickly in mice model. [18F]T807 clears rapidly from the brain, with activity values decreasing from 4.43% ID/g at 5 minutes to 0.62% ID/g at 30 minutes. Kidney elimination is a significant clearance pathway, resulting in a maximum tracer concentration of 14.99% ID/g in the kidneys at 5 minutes, which decreases to 5.52% ID/g at 30 minutes. The accumulation of activity in muscle and bone remain relatively low throughout the PET scan

參考文獻(xiàn)：

1. Xia CF, et al. [(18)F]T807, a novel tau positron emission tomography imaging agent for Alzheimer's disease. Alzheimers Dement. 2013 Nov;9(6):666-76. 2. Marquié M, et al. Validating novel tau positron emission tomography tracer [F-18]-AV-1451 (T807) on postmortem brain tissue. Ann Neurol. 2015 Nov;78(5):787-800.

溶解性：

soluble in DMSO

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	3.798 ml	18.992 ml	37.984 ml
5 mM	0.76 ml	3.798 ml	7.597 ml
10 mM	0.38 ml	1.899 ml	3.798 ml
50 mM	0.076 ml	0.38 ml	0.76 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻(xiàn)

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批號(hào)：JS298415 貨號(hào)：S20001-25g
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