貨號(hào)	規(guī)格	價(jià)格	上海	北京	武漢	南京
S83144-5mg	99.7%	￥552.00 S83144-5mg ￥552.00 現(xiàn)貨	4 4	-	-	-
S83144-10mg	99.7%	￥720.00 S83144-10mg ￥720.00 現(xiàn)貨	7 7	-	-	-
S83144-25mg	99.7%	￥1480.00 S83144-25mg ￥1480.00 現(xiàn)貨	8 8	-	-	-
S83144-100mg	99.7%	￥4640.00 S83144-100mg ￥4640.00 現(xiàn)貨	2 2	-	-	-

產(chǎn)品介紹

ML281 is a potent and selective STK33 inhibitor with IC50 of 14 nM. ML281 showed a 550-fold selectivity over AurB and greater than 700-fold selectivity over PKA. target: STK33 IC50: 14 nM [1] ML281 showed low nanomolar inhibition of purified recombinant STK33 and a distinct selectivity profile as compared to other STK33 inhibitors. Even at the highest concentration tested (10 μM), ML281 had no effect on the viability of KRAS-dependent cancer cells.

產(chǎn)品描述：

靶點(diǎn)：

STK33;SerineProtease

體外研究：

ML281 (10 μM; 72 hours) suppresses cell viability of NCI-H446 cells. Cell Viability Assay Cell Line: NCI-H446 cells Concentration: 10 μM Incubation Time: 72 hours Result: Suppressed cell viability of NCI-H446 cells.

參考文獻(xiàn)：

1. Wewer M et al. A Potent and Selective Quinoxalinone-Based STK33 Inhibitor Does Not Show Synthetic Lethality in KRAS-Dependent Cells. ACS Med Chem Lett, 2012 Dec 13, 3(12):1034-1038. 2. Sun EL, et al. Knockdown of human serine/threonine kinase 33 suppresses human small cell lung carcinoma by blocking RPS6/BAD signaling transduction. Neoplasma. 2017;64(6):869-879. 3. Spoonamore J et al. Screen for Inhibitors of STK33 Kinase Activity. National Center for Biotechnology Information (US); 2010-2011 Dec 16.

溶解性：

Soluble in DMSO

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.568 ml	12.838 ml	25.676 ml
5 mM	0.514 ml	2.568 ml	5.135 ml
10 mM	0.257 ml	1.284 ml	2.568 ml
50 mM	0.051 ml	0.257 ml	0.514 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻(xiàn)

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