貨號	規格	價格	上海	北京	武漢	南京
S83130-1mg	99.0%	￥570.00 S83130-1mg ￥570.00 現貨	10 10	-	-	-
S83130-5mg	99.0%	￥1450.00 S83130-5mg ￥1450.00 現貨	8 8	-	-	-
S83130-25mg	99.0%	￥3700.00 S83130-25mg ￥3700.00 現貨	9 9	-	-	-

產品介紹

GV-58 is a novel N- and P/Q-type calcium (Ca2+) channel agonist with EC50s of 7.21 and 8.81 μM, respectively. GV-58 slows the deactivation of channels, resulting in a large increase in presynaptic Ca2+ entry during activity. GV-58 can be used in lambert-eaton myasthenic syndrome (LEMS) research

產品描述：

靶點：

N-type calcium channel:7.21 μM (EC50);P/Q-type calcium channel:8.81 μM (EC50);CalciumChannel

體外研究：

GV-58 (50 μM; 30 min) restores function in LEMS passive transfer neuromuscular junction. Cell Viability Assay Cell Line: Upper arm muscle isolated from LEMS mice Concentration: 50 μM Incubation Time: 30 min Result: Increased the mEPP frequency from 3.27 s?1 in vehicle controls to 10.45 s?1.Showed a slight facilitation followed by depression to ～94% at the final EPP in the train.

參考文獻：

1. Tarr TB, et al. Evaluation of a novel calcium channel agonist for therapeutic potential in Lambert-Eaton myasthenic syndrome. J Neurosci. 2013 Jun 19;33(25):10559-67. 2. Tarr TB, et al. Complete reversal of Lambert-Eaton myasthenic syndrome synaptic impairment by the combined use of a K+ channel blocker and a Ca2+ channel agonist. J Physiol. 2014 Aug 15;592(16):3687-96. 3. Meriney SD, et al. Lambert-Eaton myasthenic syndrome: mouse passive-transfer model illuminates disease pathology and facilitates testing therapeutic leads. Ann N Y Acad Sci. 2018 Jan;1412(1):73-81.

溶解性：

Soluble in DMSO

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.67 ml	13.351 ml	26.702 ml
5 mM	0.534 ml	2.67 ml	5.34 ml
10 mM	0.267 ml	1.335 ml	2.67 ml
50 mM	0.053 ml	0.267 ml	0.534 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

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