| 貨號 | 規格 | 價格 | 上海 | 北京 | 武漢 | 南京 | 購買數量 |
|---|---|---|---|---|---|---|---|
S83097-1mg |
≥98% | ￥245.00 | 貨期：2-3天 | - | - | - |
|
S83097-5mg |
≥98% | ￥570.00 | 貨期：2-3天 | - | - | - |
|
S83097-10mg |
≥98% | ￥820.00 | 貨期：2-3天 | - | - | - |
|
S83097-50mg |
≥98% | ￥3200.00 | 貨期：2-3天 | - | - | - |
|
S83097-100mg |
≥98% | ￥4900.00 | 貨期：2-3天 | - | - | - |
|
PF-06291874 is a highly potent, non-peptide and orally active glucagon receptor antagonist. PF-06291874 is under the study for type 2 diabetes mellitus (T2DM)
| 產品描述： | PF-06291874 is a highly potent, non-peptide and orally active glucagon receptor antagonist. PF-06291874 is under the study for type 2 diabetes mellitus (T2DM) | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 靶點： | GCGR;GlucagonReceptor | ||||||||||||||||||||
| 體內研究： | PF-06291874 exposure is approximately dose-proportional with a half-life of ～19.7-22.7 h. PF-06291874 has a fast on and off rate. PF-06291874 is highly bound to human plasma protein, with a mean free fraction of ～0.55% | ||||||||||||||||||||
| 參考文獻： | 1. Esther C.Y. Lee et al. Identification of a novel conformationally constrained glucagon receptor antagonist. Bioorg Med Chem Lett, 2014 Feb 1, 24(3):839-44. 2. Derek J Nunez, et al. Glucagon receptor as a drug target: A witches' brew of eye of newt (peptides) and toe of frog (receptors). Diabetes Obes Metab. 2018 Feb;20(2):233-237. 3. D J Kazierad, et al. Effects of multiple ascending doses of the glucagon receptor antagonist PF-06291874 in patients with type 2 diabetes mellitus. Diabetes Obes Metab. 2016 Aug;18(8):795-802. | ||||||||||||||||||||
| 溶解性： | soluble in DMSO | ||||||||||||||||||||
| 保存條件： | -20℃ | ||||||||||||||||||||
| 配置溶液濃度參考： |
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| 注意： | 部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。 |
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危險品化學品經營許可證（不帶存儲）
營業執照(三證合一)
北京