貨號	規格	價格	上海	北京	武漢	南京
S83069-5mg	≥98%	￥340.00 S83069-5mg ￥340.00 2-3天	0 貨期：2-3天	-	-	-
S83069-10mg	98.1%	￥433.50 S83069-10mg ￥433.50 現貨	6 6	-	-	-
S83069-25mg	98.1%	￥952.00 S83069-25mg ￥952.00 現貨	8 8	-	-	-
S83069-100mg	98.1%	￥1950.00 S83069-100mg ￥1950.00 現貨	1 1	-	-	-

產品介紹

BD-1047 (dihydrobromide) is a selective functional antagonist of sigma-1 receptor, shows antipsychotic activity in animal models predictive of efficacy in schizophrenia

產品描述：

BD-1047 (dihydrobromide) is a selective functional antagonist of sigma-1 receptor, shows antipsychotic activity in animal models predictive of efficacy in schizophrenia

靶點：

sigma-1 receptor;Sigmareceptor

體外研究：

BD-1047 (dihydrobromide) prevents that Cutamesine reduces the cell death rate induced by light exposure in murine photoreceptor-derived 661w cells.
BD-1047 (dihydrobromide) attenuates that Cutamesine reduces the mitochondrial damage and the elevated level of caspase 3/7 activity.

體內研究：

BD-1047 (dihydrobromide) (1-10 mg/kg; i.p.) decreases the Apomorphine (APO)-induced climbing behavior at the dose of 10 mg/kg in mice. BD-1047 (dihydrobromide) counteracts the antidepressant-like effect induced by co-administration of pramipexole and sertraline (but not pramipexole and fluoxetine). BD-1047 (dihydrobromide) reduces the increasing expression of pNR1, and reverses the Sig-1 R agonists potentiated NMDA-induced pain behaviour and pNR1 immunoreactivity. Animal Model: Male Albino Swiss mice (50 days old, 25–28 g) Dosage: 1 mg/kg, 3 mg/kg, 10 mg/kg Administration: Intraperitoneal injection Result: Decreased the APO-induced climbing at the dose of 10 mg/kg in mice.

參考文獻：

1. Skuza G, et al. Effect of BD 1047, a sigma1 receptor antagonist, in the animal models predictive of antipsychotic activity. Pharmacol Rep. 2006 Sep-Oct;58(5):626-635. 2. Shimazawa M, et al. Effect of a sigma-1 receptor agonist, cutamesine dihydrochloride (SA4503), on photoreceptor cell death against light-induced damage. Exp Eye Res. 2015 Mar;132:64-72. 3. Rogóz Z, et al. Mechanism of synergistic action following co-treatment with pramipexole and fluoxetine or sertraline in the forced swimming test in rats. Pharmacol Rep. 2006 Jul-Aug;58(4):493-500.

溶解性：

Soluble in DMSO、H2O

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.288 ml	11.441 ml	22.881 ml
5 mM	0.458 ml	2.288 ml	4.576 ml
10 mM	0.229 ml	1.144 ml	2.288 ml
50 mM	0.046 ml	0.229 ml	0.458 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

質檢證書(COA)

輸入產品批號：

如何獲取質檢證書(COA)?

請輸入貨號和一個與之匹配的批號。
例如:
批號：JS298415 貨號：S20001-25g
在貨品標簽上如何找到貨號和批號?

摩爾濃度計算器

質量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)

質量

濃度

體積

分子摩爾量

計算重置

玖玖资源网站,爆乳久久久,日韩精品乱码久久久蜜桃,精品呦国产一区二区三区,国产伦高清一区二区三区,sese一区二区,午夜精品福利一区二区三区,三级黄色网站久久免费

BD1047 HBr

BD-1047 (dihydrobromide)