貨號	規格	價格	上海	北京	武漢	南京
S83063-1mg	98.1%	￥246.00 S83063-1mg ￥246.00 現貨	10 10	-	-	-
S83063-5mg	98.1%	￥450.50 S83063-5mg ￥450.50 現貨	5 5	-	-	-
S83063-10mg	98.1%	￥731.00 S83063-10mg ￥731.00 現貨	6 6	-	-	-
S83063-25mg	98.1%	￥1402.50 S83063-25mg ￥1402.50 現貨	6 6	-	-	-
S83063-50mg	98.1%	￥2720.00 S83063-50mg ￥2720.00 現貨	5 5	-	-	-
S83063-100mg	≥98%	￥4900.00 S83063-100mg ￥4900.00 2-3天	0 貨期：2-3天	-	-	-

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產品介紹

KML29 is an extremely selective, orally active and irreversible MAGL inhibitor, with IC50 values of 15 nM, 43 nM and 5.9 nM for mouse, rat and human MAGL, respectively. KML29 exhibits minimal cross-reactivity toward other central and peripheral serine hydrolases, including no detectable activity against FAAH

產品描述：

靶點：

IC50: 15 nM (mouse MAGL), 43 nM (rat MAGL), 5.9 nM (human MAGL);Lipase

體內研究：

KML29 enhibits antinociceptive activity without cannabimimetic side effects. KML29 (20 mg/kg) has a significant but modest protective effect against LPS-induced fever

參考文獻：

1. Natsuo Ueda, et al. Discrimination between two endocannabinoids. Chem Biol. 2012 May 25;19(5):545-7.2. Jae Won Chang, et al. Highly selective inhibitors of monoacylglycerol lipase bearing a reactive group that is bioisosteric with endocannabinoid substrates. Chem Biol. 2012 May 25;19(5):579-88. 3. B M Ignatowska-Jankowska, et al. In vivo characterization of the highly selective monoacylglycerol lipase inhibitor KML29: antinociceptive activity without cannabimimetic side effects. Br J Pharmacol. 2014 Mar;171(6):1392-407.

溶解性：

DMSO : 50 mg/mL (91.01 mM; Need ultrasonic)

保存條件：

2-8℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	1.82 ml	9.101 ml	18.201 ml
5 mM	0.364 ml	1.82 ml	3.64 ml
10 mM	0.182 ml	0.91 ml	1.82 ml
50 mM	0.036 ml	0.182 ml	0.364 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

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KML-29