貨號	規(guī)格	價格	上海	北京	武漢	南京
S83061-1mg	99.8%	￥300.00 S83061-1mg ￥300.00 現(xiàn)貨	6 6	-	-	-
S83061-2mg	99.8%	￥390.00 S83061-2mg ￥390.00 現(xiàn)貨	7 7	-	-	-
S83061-5mg	99.8%	￥490.00 S83061-5mg ￥490.00 現(xiàn)貨	7 7	-	-	-
S83061-10mg	99.8%	￥740.00 S83061-10mg ￥740.00 現(xiàn)貨	6 6	-	-	-
S83061-25mg	99.8%	￥1330.00 S83061-25mg ￥1330.00 現(xiàn)貨	5 5	-	-	-
S83061-50mg	≥98%	￥2160.00 S83061-50mg ￥2160.00 2-3天	0 貨期：2-3天	-	-	-
S83061-100mg	≥98%	￥3800.00 S83061-100mg ￥3800.00 2-3天	0 貨期：2-3天	-	-	-

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產(chǎn)品介紹

GAL-021 is a potent BKCa-channel blocker. GAL-021 inhibits KCa1.1 in GH3 cells. GAL-021 is a novel breathing control modulator that is based on selective modification of the almitrine pharmacophore. GAL-021 increases minute ventilation in rats and non-human primates

產(chǎn)品描述：

靶點：

Potassium Channel;PotassiumChannel

體外研究：

GAL-021 is being developed as a novel breathing control modulator to preserve respiratory drive and protect patients from respiratory impairment due to opioids and other modalities. Using inside-out patches in GH3 cells, GAL-021 exerts concentration-dependent inhibition of single-channel KCa1.1 activity. When evaluated against 12 different cardiac ion channels, inhibition is 35% or less at 30 μM. No significant kinase inhibition is observed at 10 μM. At 30 μM in the radioligand binding assays, interactions (defined as >50% radioligand displacement) are detected at adenosine A1 (65% I), A2A (79% I, IC50 approximately 5μM), and A3 (93% I; IC50 approximately 1 μM) receptors, at 5-HT2B receptors (60% I; IC50 approximately 30 μM)

體內(nèi)研究：

Intravenously administered GAL-021 attenuates opiate-induced respiratory depression in rats and nonhuman primates without affecting analgesia in rats. GAL-021 ventilatory stimulation in rats is attenuated by carotid sinus nerve transection. GAL-021 ventilatory stimulation is attenuated in mice lacking the pore-forming α-subunit of the KCa 1.1 channel

參考文獻(xiàn)：

1. Golder FJ, et al. Identification and Characterization of GAL-021 as a Novel Breathing Control Modulator. Anesthesiology. 2015 Nov;123(5):1093-104. 2. J F McLeod, et al. GAL-021, a new intravenous BKCa-channel blocker, is well tolerated and stimulates ventilation in healthy volunteers. Br J Anaesth. 2014 Nov;113(5):875-83.

溶解性：

Soluble in DMSO

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	3.932 ml	19.659 ml	39.319 ml
5 mM	0.786 ml	3.932 ml	7.864 ml
10 mM	0.393 ml	1.966 ml	3.932 ml
50 mM	0.079 ml	0.393 ml	0.786 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻(xiàn)

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