| 貨號 | 規格 | 價格 | 上海 | 北京 | 武漢 | 南京 | 購買數量 |
|---|---|---|---|---|---|---|---|
S83048-2mg |
99.9% | ￥150.00 | 8 | - | - | - |
|
S83048-1mg |
99.9% | ￥280.00 | 9 | - | - | - |
|
S83048-10mg |
99.9% | ￥325.00 | 6 | - | - | - |
|
S83048-25mg |
99.9% | ￥560.00 | 5 | - | - | - |
|
S83048-5mg |
99.9% | ￥807.00 | 8 | - | - | - |
|
S83048-50mg |
≥98% | ￥890.00 | 貨期：2-3天 | - | - | - |
|
S83048-100mg |
≥98% | ￥1490.00 | 貨期：2-3天 | - | - | - |
|
PBTZ169 inhibits decaprenylphosphoryl-β-d-ribose 2′-oxidase (DprE1), more efficiently than BTZ043.
| 產品描述： | PBTZ169 inhibits decaprenylphosphoryl-β-d-ribose 2′-oxidase (DprE1), more efficiently than BTZ043. | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 靶點： | Antibacterial;DprE1;Antibacterial;?DprE1 | ||||||||||||||||||||
| 體外研究： | PBTZ169, inhibit decaprenylphosphoryl-β-d-ribose 2′-oxidase (DprE1) and display nanomolar bactericidal activity against Mycobacterium tuberculosis in vitro. | ||||||||||||||||||||
| 體內研究： | PBTZ169 can be suspend in 0.25% hydroxy-propylmethyl-cellulose. The administertration for PBTZ169 is 100 mg/kg by gavage. The MIC50 and MIC90 values were 0.0075 and 0.030 μg/mL, respectively. The MIC for PBTZ169 for N. brasiliensis HUJEG-1 was 0.0037 μg/mL. PBTZ169 has improved potency, safety and efficacy in zebrafish and mouse models of tuberculosis (TB). | ||||||||||||||||||||
| 參考文獻： | 1. Makarov V,et al. The 8-Pyrrole-Benzothiazinones Are Noncovalent Inhibitors of DprE1 from Mycobacterium tuberculosis. Antimicrob Agents Chemother. 2015 Aug;59(8):4446-52. 2. González-Martínez NA,et al. In Vivo Activity of the Benzothiazinones PBTZ169 and BTZ043 against Nocardia brasiliensis. PLoS Negl Trop Dis. 2015 Oct 16;9(10):e0004022. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO | ||||||||||||||||||||
| 保存條件： | -20℃ | ||||||||||||||||||||
| 配置溶液濃度參考： |
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| 注意： | 部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。 |
上海工商
滬公網安備 31011702002021號
危險品化學品經營許可證（不帶存儲）
營業執照(三證合一)
北京