貨號	規格	價格	上海	北京	武漢	南京
S83036-5mg	99.8%	￥425.00 S83036-5mg ￥425.00 現貨	6 6	-	-	-
S83036-10mg	99.8%	￥680.00 S83036-10mg ￥680.00 現貨	7 7	-	-	-
S83036-25mg	99.8%	￥1360.00 S83036-25mg ￥1360.00 現貨	6 6	-	-	-
S83036-100mg	≥98%	￥4207.00 S83036-100mg ￥4207.00 2-3天	0 貨期：2-3天	-	-	-

產品介紹

BRD9539 is a histone methyltransferase G9a inhibitor with an IC50 of 6.3 μM. BRD9539 also inhibits PRC2 activity and is inactive against SUV39H1, NSD2 and DNMT1

產品描述：

BRD9539 is a histone methyltransferase G9a inhibitor with an IC50 of 6.3 μM. BRD9539 also inhibits PRC2 activity and is inactive against SUV39H1, NSD2 and DNMT1

靶點：

G9a:6.3 μM (IC50);PRC2;HistoneMethyltransferase

體外研究：

BRD9539 decreases ATP levels in a dose-dependent manner in HeLa cells.
BRD9539 is a more potent biochemical inhibitor than its methyl-ester analogue BRD4770, with 20% remaining G9a activity compared to 45% of BRD4770 at screening concentration. However, BRD9539 has no activity in cell-based assays, presumably due to impaired cell permeability compared to that of BRD4770. In addition, the activities of 16 other chromatin-modifying enzymes and 100 kinases involved in cell-cycle regulation and cancer cell biology are tested for activity in the presence of 5 or 10 μM BRD9539; no activity is seen in any of these assays.

參考文獻：

1. Yuan, Y., Wang, Q., Paulk, J., et al. A small-molecule probe of the histone methyltransferase G9a induces cellular senescence in pancreatic adenocarcinoma ACS Chem. Biol. 7(7), 1152-1157 (2012).

溶解性：

Soluble in DMSO

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.503 ml	12.517 ml	25.035 ml
5 mM	0.501 ml	2.503 ml	5.007 ml
10 mM	0.25 ml	1.252 ml	2.503 ml
50 mM	0.05 ml	0.25 ml	0.501 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

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BRD9539

2-benzamido-1-(3-phenylpropyl)-1H-1,3-benzodiazole-5-carboxylic acid