| 貨號 | 規格 | 價格 | 上海 | 北京 | 武漢 | 南京 | 購買數量 |
|---|---|---|---|---|---|---|---|
S83035-2mg |
99.1% | ￥260.00 | 8 | - | - | - |
|
S83035-5mg |
99.1% | ￥360.00 | 7 | - | - | - |
|
S83035-10mg |
99.1% | ￥670.00 | 2 | - | - | - |
|
S83035-25mg |
99.1% | ￥1496.00 | 4 | - | - | - |
|
S83035-50mg |
99.1% | ￥2652.00 | 4 | - | - | - |
|
S83035-100mg |
99.1% | ￥5032.00 | 2 | - | - | - |
|
S83035-300mg |
99.1% | ￥11000.00 | 1 | - | - | - |
|
TUG-891是一種有效的、選擇性 long chain free fatty acid (LCFA) receptor 4 (FFA4/GPR120) 激動劑
| 產品描述： | TUG-891是一種有效的、選擇性 long chain free fatty acid (LCFA) receptor 4 (FFA4/GPR120) 激動劑 | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 靶點： | FFA4/GPR120;GPR | ||||||||||||||||||||
| 體外研究： | TUG-891 displays similar signaling properties to the LCFA α-linolenic acid at human FFA4 across various assay end points, including stimulation of Ca2? mobilization, β-arrestin-1 and β-arrestin-2 recruitment, and extracellular signal-regulated kinase phosphorylation. Activation of human FFA4 by TUG-891 also results in rapid phosphorylation and internalization of the receptor | ||||||||||||||||||||
| 體內研究： | TUG-891 acutely increases fat oxidation and reduces body weight and fat mass in C57Bl/6J mice by activating GPR120 | ||||||||||||||||||||
| 細胞實驗： | Cell lines: Human FFA4-eYFP Flp-In T-REx cells, HT-29 cells Concentrations: 10 μM Incubation Time: 1.5 min, 5 min, 45 min Method: Intracellular Ca2+ is monitored for 1.5 min after TUG-891 treatment, and the measured response is taken as the peak signal over this time course. Extracellular signal-regulated kinase 1/2 (ERK) phosphorylation is examined in Flp-In T-REx cell lines, or in HT-29 cells after 5 minutes of TUG-891 treatment. For visualization of FFA4 Internalization, human FFA4-eYFP Flp-In T-REx cells are cultured on poly-d-lysine coated glass coverslips and cultured for 24 hours before treatment with doxycycline (100 ng/ml) to induce receptor expression. Live cells are imaged after TUG-891 addition using a confocal microscopy system. | ||||||||||||||||||||
| 參考文獻： | 1. Hudson BD, et al. The pharmacology of TUG-891, a potent and selective agonist of the free fatty acid receptor 4 (FFA4/GPR120), demonstrates both potential opportunity and possible challenges to therapeutic agonism. Mol Pharmacol. 2013 Nov;84(5):710-25. 2. Schilperoort M, et al. The GPR120 agonist TUG-891 promotes metabolic health by stimulating mitochondrial respiration in brown fat. EMBO Mol Med. 2018 Mar;10(3):e8047. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO、Ethanol | ||||||||||||||||||||
| 保存條件： | -20℃ | ||||||||||||||||||||
| 配置溶液濃度參考： |
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| 注意： | 部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。 |
上海工商
滬公網安備 31011702002021號
危險品化學品經營許可證（不帶存儲）
營業執照(三證合一)
北京