| 貨號 | 規格 | 價格 | 上海 | 北京 | 武漢 | 南京 | 購買數量 |
|---|---|---|---|---|---|---|---|
S82991-1mg |
99.9% | ￥100.00 | >10 | - | - | - |
|
S82991-2mg |
99.9% | ￥150.00 | >10 | - | - | - |
|
S82991-5mg |
99.9% | ￥220.00 | >10 | - | - | - |
|
S82991-10mg |
99.9% | ￥320.00 | 9 | - | - | - |
|
S82991-25mg |
99.9% | ￥520.00 | 9 | - | - | - |
|
S82991-50mg |
99.9% | ￥800.00 | 6 | - | - | - |
|
S82991-100mg |
99.9% | ￥1400.00 | 3 | - | - | - |
|
TP-3654 is a second-generation Pim kinase inhibitor with Ki values of 5 and 42 nM for Pim-1 and Pim-3, respectively.
| 產品描述： | TP-3654 is a second-generation Pim kinase inhibitor with Ki values of 5 and 42 nM for Pim-1 and Pim-3, respectively. | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 靶點： | Ki: 5 nm(Pim-1), 239 nM (Pim-2), 42 nM (Pim-3);Pim | ||||||||||||||||||||
| 體外研究： | TP-3654 demonstrates potent PIM-1 specific cellular activity in the PIM-1/BAD overexpression system with an average EC50 of 67 nM. TP-3654 treatment reduces levels of phospho-BAD in vitro using the bladder cancer cell line UM-UC-3. TP-3654 reduces colony growth of T24 and UM-UC3 cells, confirming the PIM-1–dependent growth for both cell lines | ||||||||||||||||||||
| 體內研究： | Oral dosing of 200 mg/kg TP-3654 significantly reduces both UM-UC-3 and PC-3 tumor growth measured by volume (caliper) and by final tumor weight, with no significant changes in body weight or gross adverse toxicity | ||||||||||||||||||||
| 參考文獻： | 1. Foulks JM, et al. A small-molecule inhibitor of PIM kinases as a potential treatment for urothelial carcinomas. Neoplasia. 2014 May;16(5):403-12. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO | ||||||||||||||||||||
| 保存條件： | -20℃ | ||||||||||||||||||||
| 配置溶液濃度參考： |
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| 注意： | 部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。 |
上海工商
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危險品化學品經營許可證（不帶存儲）
營業執照(三證合一)
北京